Page 8 - Human Umbilical Cord Mesenchymal Stem Cells

MSCs transplantation for osteoarthritis treatment

Fig 3. Forest plots of MD with 95% CI in IKDC between patients undergoing MSC therapy and controls at: (1) 6 months, (2) 12
months, and (3) 24 months. Random-effects models were used.
https://doi.org/10.1371/journal.pone.0175449.g003

MSC treatment groups and controls [27,31]. Moreover, no serious AEs related to MSC
implantation were developed in the 11 selected publications. Another review also reported that
the application of cultured stem cells in joints appeared to be safe [36].

4. Discussion
Knee OA is a progressive and degenerative condition, which will remain a serious clinical
problem in orthopedics unless significant advancements are made in regeneration

Fig 4. Forest plots of MD with 95% CI in WOMAC between patients undergoing MSC therapy and controls at 12 months. Fixed-
effects models were used.
https://doi.org/10.1371/journal.pone.0175449.g004

PLOS ONE | https://doi.org/10.1371/journal.pone.0175449 April 27, 2017 8 / 16