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Prevalence and Risk Factors of High N-Terminal Pro B-Type
Natriuretic Peptide (NT-proBNP) in Diabetes Patients with
High-Risk for Diabetic Foot Ulcer
Kongporn Noisang1, Thipaporn Tharavanij1,2,3, Adisai Buakhamsri4, Nattamon Tanathornkirati3
,
Palakorn Puttaruk5, Akarabhat Sakdavisarak6, Natthapon Kaewprasert7, Thanawat Ruengchaisiwawaith8*
1 Endocrinology Unit, Department of Internal Medicine, Thammasat University
2 Center of Excellence in Applied Epidemiology, Thammsat University
3 Thammasat Diabetes Center of Excellence, Thammasat University Hospital
4 Cardiology Unit, Department of Internal Medicine, Thammasat University
5 Department of Medical Technology Laboratory, Thammasat University Hospital
6 St. Andrews International School Bangkok
7 Endocrinology and Metabolism Unit, Department of Internal Medicine, Bhumibol Adulyadej Hospital
8 Cardiology Unit, Department of Internal Medicine, Bhumibol Adulyadej Hospital
*Corresponding Author E-mail: beroppeach@gmail.com
Background: Methods: Abstract
Patients with a high-risk for diabetic foot ulcer (DFU) usually have micro- and/or
macrovascular complications. Therefore, this population may have a high prevalence
of pre-heart failure (stage B heart failure). The N-terminal pro B-type natriuretic peptide
(NT-proBNP) is recommended for pre-heart failure yearly screening in diabetic patients.
This study aimed to explore the prevalence and risk factors of elevated NT-proBNP
in diabetic patients with high-risk for DFU.
A cross-sectional study was conducted among 57 diabetes participants with high-risk for
DFU (peripheral neuropathy and/or peripheral vascular disease plus the current or history of
DFU or amputation). Patients with heart diseases, active infection, eGFR < 30 ml/min/1.732
,
hemoglobin < 8 g/dl, and body mass index > 35 kg/m2 were excluded. The NT-proBNP
levels were performed using the electrochemiluminescence immunoassay. Data was
presented in mean±SD or median (interquartile range). Multiple logistic regression was
used to explore the associated factors.
Harmony in health: Innovation for Sustainable Medicine
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