Page 112 - Quanta BioDesign Catalog 5-17-18

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dPEG Based Reagents for Peptide Modification

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Fmoc-amidooxy-dPEG acid
12

 Aldehydes (latent) are common in carbohydrates, carbohydrate containing proteins, and other oxidizable matrices;
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and can be incorporated using reagents like the 4-FB-dPEG x TFP esters (amine reactive).
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 Aminooxy-dPEG s and peptide synthesis: These reagents can be incorporated as the final step to the N-terminus of
the peptide, which with simple deprotection will provide a selective linkage to an aldehyde of a ketone - Aniline
catalysis avails us to both of these; the ketone can be more stable, especially if going into an aqueous reaction
medium.

Product # Description 100 mg 1000 mg
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10849 Fmoc-amidooxy-dPEG 12 acid $175 $850

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Mol. Wt.: 855.96; single compound; dPEG Spacer is 41 atoms and 47.6 Å
References:
nd
 Greg T. Hermanson, Bioconjugate Techniques, 2 Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0)., See pp. 276-335
for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SPDP and LC-SPDP on pp. 286-288. See Greg’s extensive index on pg. 1192-
1193 for references to a number and range of applications and their respective protocols.
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 Greg T. Hermanson, Bioconjugate Techniques, 3 Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full
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overview of the dPEG products.
Products Protected under U.S. Patents # 7,888,536 & 8,637,711

For technical questions, please call 614-792-2958 or contact info@quantabiodesign.com 106