Page 203 - Atlas of Small Animal CT and MRI

Metabolic, Toxic, and Degenerative Disorders 193

Figure 2.5.9 Presumptive Metronidazole Toxicity (Canine) MR

(a) T1, TP (b) T2, TP (c) FL, TP

(d) T2, DP (e) T2, SP (f) T1+C, TP
11y FS Poodle with a history of inflammatory bowel disease being treated long‐term with metronidazole. Current neurologic signs
include nystagmus and rolling. Symmetrical T2 and FLAIR hyperintensity of the dentate nuclei is present (b–e: arrowheads). There is no
visible abnormality on the unenhanced T1 image (a) and no evidence of contrast enhancement (f). MR features are consistent with
metronidazole neurotoxicity, and both serum and cerebrospinal fluid were positive for metronidazole on liquid chromatography/mass
spectrometry analysis.

Figure 2.5.10 Age‐related Degeneration (Canine) MR

12y MC Shiba Inu with left‐sided vestibular
signs. There is prominence of the subarachnoid
space and lateral ventricles due to corti-
cal atrophy (a,b). The cortical mantle is thin,
and gyri are smaller than expected. The
hippocampus also appears small with central
foci of increased T2 intensity (b: arrows). No
other abnormalities were detected on the MR
examination, and clinical signs resolved after
approximately 2 weeks.

(a) T1+C, TP (b) T2, TP
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