Page 204 - Atlas of Small Animal CT and MRI

194 Atlas of Small Animal CT and MRI

Figure 2.5.11 Alaskan Husky Encephalopathy (Canine) MR

(a) FL, TP (b) FL, TP (c) T2, TP

(d) T2, SP (e) T1+C, TP
9mo MC Alaskan Husky with ataxia, tetraparesis, and absent postural reactions. There are multiple focal T2 and FLAIR hyperintense
lesions in the caudate nucleus (a: small arrowhead), putamen (a: large arrowhead), thalamus (b,c: arrowhead), red nucleus, and medulla
(d: arrows). There are also ill‐defined regions of T2 and FLAIR hyperintensity at the gray–white matter interface of the cerebrum (a–c:
arrows). Thalamic lesions minimally and peripherally contrast enhance (e: arrowheads). Postmortem examination revealed severe
bilaterally symmetrical encephalomalacia involving basal nuclei, thalamus, midbrain, pons, cerebral cortex, and cerebellar vermis gray
matter, consistent with Alaskan Husky encephalopathy.

References accumulation in the retinas and brains of Tibetan Terriers with
ceroid‐lipofuscinosis. Am J Vet Res. 2005;66:67–76.
1. Evans J, Katz ML, Levesque D, Shelton GD, de Lahunta A, O’Brien 6. Koie H, Shibuya H, Sato T, Sato A, Nawa K, Nawa Y, et al. Magnetic
D. A variant form of neuronal ceroid lipofuscinosis in American resonance imaging of neuronal ceroid lipofuscinosis in a border
bulldogs. J Vet Intern Med. 2005;19:44–51. collie. J Vet Med Sci. 2004;66:1453–1456.
2. Jolly RD, Hartley WJ, Jones BR, Johnstone AC, Palmer AC, Blakemore 7. Nakamoto Y, Yamato O, Uchida K, Nibe K, Tamura S, Ozawa T,
WF. Generalised ceroid‐lipofuscinosis and brown bowel syndrome in et al. Neuronal ceroid‐lipofuscinosis in longhaired Chihuahuas:
Cocker spaniel dogs. N Z Vet J. 1994;42:236–239. clinical, pathologic, and MRI findings. J Am Anim Hosp Assoc.
3. Jolly RD, Sutton RH, Smith RI, Palmer DN. Ceroid‐lipofuscinosis 2011;47:e64–70.
in miniature Schnauzer dogs. Aust Vet J. 1997;75:67. 8. Narfstrom K, Wrigstad A, Ekesten B, Berg AL. Neuronal ceroid
4. Katz ML, Khan S, Awano T, Shahid SA, Siakotos AN, Johnson GS. lipofuscinosis: clinical and morphologic findings in nine affected
A mutation in the CLN8 gene in English Setter dogs with neuronal Polish Owczarek Nizinny (PON) dogs. Vet Ophthalmol. 2007;
ceroid‐lipofuscinosis. Biochem Biophys Res Commun. 2005; 10:111–120.
327:541–547. 9. O’Brien DP, Katz ML. Neuronal ceroid lipofuscinosis in 3
5. Katz ML, Narfstrom K, Johnson GS, O’Brien DP. Assessment of Australian shepherd littermates. J Vet Intern Med. 2008;22:
retinal function and characterization of lysosomal storage body 472–475.
194