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Orthopedic
Frodosome -
new organelle
named after
'the hobbit' hero
Scientists have recently discovered a
new membrane-less fluid-like
structure involved in bone metastasis.
It is unofficially named as the
"frodosome" or "wise" organelle.
It was discovered accidently while
scientist were studying DACT1 gene
which suppresses critical signaling
pathways in cells that help in early
bone development and influence
cancer progression. The researchers
think that frodosomes form when the
protein DACT1 binds to other
free-floating proteins and molecules
in the cell.
The DCT1 gene regulates the Wnt
signaling pathway of cancer
metastasis. The frodosome plays a
part in the spread of bone tumor by
suppressing the Wnt pathway.
It's too early to say whether the
frodosome will be a good drug
target in metastatic cancer, but the
discovery is definitely an exciting
phenomenon.
Osteomorphs – the surgical robots
power ranger bone cells
Orthopedic procedures using robots are less
Institute of Medical Research have intrusive and deliver reproducible accuracy,
discovered a new type of bone cell resulting in shorter hospital stays and quicker
called ‘osteomorphs’ that may recovery times.
reveal new therapeutic approaches
for osteoporosis and other skeletal i. Semi-active robots-
diseases. Osteoclasts split into By offering an eminent combination of
smaller fragments to form flexibility and accuracy, these robots are
osteomorphs which fuse together outperforming the conventional orthopedic
forming osteoclasts again. surgical robots and proving their mettle in
Therefore, the cosmos has called it delivering effective care. Semi-active robots
a “recyclable cell”. also provide user-friendly interfaces for easy
Figure - 3D microscopy image of
access and make the surgeries minimally
osteomorphs
They are also found in the blood invasive as well as highly accurate.
(source-cosmosmagazine.com)
and bone marrow wherein they are Smart sensors will have
maintained as reserve of cells that ii. Patient-specific templates
A better understanding of these
are ready to fuse and deploy when cells and the genes that control These templates enable the development of applications in four arenas-
osteoclasts are needed again.
3-dimensional surgical plans for
them may reveal new therapeutic
Researchers found that 17 out of a targets for skeletal disease. implementation, along with rapid designing i. Smart Tools in the OR: Smart instruments with embed-
total of 40 genes detected in
osteomorphs impact the amount of rug-targets-for-osteoporosis-and-other-s and manufacturing of tailor-made drilling and ded sensors will help surgeons position the implant and balance
cutting templates. Robotic intervention in
bone and bone strength, indicating keletal-diseases/ orthopedic surgeries offers immense scope for the load during surgery.
a critical role in bone maintenance.
the effective application of these templates
2.https://cosmosmagazine.com/science/ ii. Smart Diagnostics on Demand: It will relay diagnos-
During animal experiments have biology/new-recyclable-bone-cell/ onto the affected joint surfaces.
been linked to human gene tic data from inside the patient to the surgeon during regular
variants that lead to skeletal 3.https://www.eurekalert.org/pub_releas patient follow-up visits.
dysplasia and control bone mineral es/2021-02/giom-nto021821.php#:~:text= Smart sensors for better
The%20new%20cells%2C%20which%20t diagnosis and iii. Smart Diagnostics by Exception: It will send
he,yet%20unexplored%20targets%20for
density. %20therapy. wireless data when they detect issues, like early infection,
Source - patient-care osteolysis and stress shielding.
1.https://www.genengnews.com/news/new-
bone-cell-type-identified-could-point-to-d Smart implants provide built-in sensors to
offer real-time tracking and post-operative iv. Treatment by Exception: It will detect a problem and
evaluation details to surgeons for better “self-treat” the patient by delivering drug therapies or stimula-
tion locally as needed. They may deliver antibiotics or growth
patient safety across the clinical process. factors long after surgery.
Source -
1.https://www.news-medical.net/news/20210309/Princeton-researche
rs-discover-previously-unknown-organelle-that-plays-role-in-bone-m
etastasis.aspx
Source -
2.https://www.livescience.com/new-frodosome-organelle-cancer.html 1.https://www.persistencemarketresearch.com/market-research/orthopedic-s
urgical-robots-market.asp
3.https://www.princeton.edu/news/2021/03/09/princeton-team-disco 2.https://orthostreams.com/2020/09/update-on-the-12-major-surgical-roboti
cs-systems-today/
vers-new-organelle-involved-cancer-metastasis#:~:text=Princeton%20 3.https://orthostreams.com/disruptive-trend-in-orthopedics-the-smart-impla
cancer%20researchers%20Yibin%20Kang,materials%20merge%20into nt-revolution/
%20each%20other. 4.https://www.imcgrupo.com/the-latest-technological-innovations-in-orthop
edic-surgery-2020-technology/
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Smart the latest technologies and inventions in orthopedics. This information is sourced from
sensors various online resources and may contain repetition of words, thoughts and ideas