Page 142 - ebook HCC

PROGRAMME AND ABSTRACTSAND ABSTRACTS
140
140 PROGRAMME GENEVA, SWITZERLAND EASL HCC SUMMIT 141
FEBRUARY 13 - 16, 2014

Poster Board Number B32

IMMUNOHISTOCHEMICAL FEATURES OF NOTES
HEPATIC ADENOMAS IN MEN

Renumathy Dhanasekaran , Yoo Na Kang , Rory Smoot , Catherine D. Moser ,
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Gregroy Gores , Tsung-Teh Wu , Taofic Mounajjed , Lewis R. Roberts 1
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1 Gastroenterology and Hepatology, Mayo Clinic, Rochester, Rochester, United States
Corresponding author’s e-mail: renumathyd@gmail.com
Introduction: Hepatic adenomas (HA) are benign tumors which were almost always
reported in women. But more recent literature has been describing an increase in the
incidence of this tumor among men. Since hepatic adenomas are rare in men, their
histopathologic and immunochemistry characteristics are not well understood.
Aims: To compare immunohistochemical features of hepatic adenomas between men and
women to identify phenotypic gender differences. We will also compare demographics and
clinical features between men and women.
Methodology: Patients who underwent surgical resection at a single center were included
in this study and were stratified based on gender. We compared clinical, histopathologic
BASIC POSTER ABSTRACTS staining for liver-fatty acid binding protein (L-FABP), serum amyloid A (SAA), glutamine BASIC POSTER ABSTRACTS
and immunohistochemistry data in patients with a diagnosis of HA. Immunohistochemical
synthetase (GS) and β-catenin (BC) were used to classify adenomas.
Results: A total of 188 nodules were resected from 105 patients. Men comprised 11.4%
(n=12) of the study group and had 16% (n=30) of the nodules. Overall 50% of the men
had multiple nodules and 25% had adenomatosis (>10 nodules). Two of them had an
underlying diagnosis of glycogen storage disorder and the rest of the adenomas were
sporadic. A high incidence (42%) of overweight/obese individuals was seen but the mean
BMI was not statistically different between men and women.
The largest subgroup by immunohistochemical staining was inflammatory adenomas
which were defined by abnormal SAA staining with BC negativity (41.4%). Steatotic
LFABP-ve nodules were the second most common subgroup (25%). One of the nodules
was beta catenin positive and one nodule showed isolated GS positivity. Men had a higher
percentage of inflammatory adenomas than women (p=0.039) and a trend towards a lower
percentage of steatotic tumors (p=0.060). BMI was not different between patients with the
different subtypes of hepatic adenomas.
Conclusions: This study reports immunohistochemistry features of hepatic adenomas
in one of the largest cohorts of men with this benign tumor. Based on our study results,
hepatic adenomas are not uncommon among men with no underlying risk factors and half
of them had multiple tumors. A higher rate of inflammatory adenomas and lower rate of
steatotic adenomas were noted in men than in women.