Page 253 - ebook HCC

EASL HCC SUMMITHCC SUMMIT
GENEVA, SWITZERLANDA, SWITZERLAND
PROGRAMME
251
250 PROGRAMME AND ABSTRACTSAND ABSTRACTS GENEV EASL 251
250
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
FEBRUAR
Poster Board Number C35
ACOUSTIC RADIATION FORCE IMPULSE (ARFI)
IN PREDICTING POST-RADIOEMBOLIZATION
(TARE) LIVER FAILURE IN PATIENTS
WITH INTERMEDIATE AND ADVANCED
HEPATOCELLULAR CARCINOMA (HCC)

Adriano De Santis , Claudia Iegri , Marinella Lupo , Giulia Gallusi , Mariana Forlino , Clinical characteristics of enrolled population
1
1
1
1
1
Chiara Bassanelli , Carmela A. Di Ciesco , Giuseppe Pizzi , Adolfo F. Attili 1 at baseline (n=21)
1
2
1
1 La Sapienza University Clinical Medicine Department, Gastroenterology Division,
2 Department of Interventional Radiology, Cancer National Institute Regina Elena, Age (years, mean + ds) 66.7 + 10
Rome, Italy
Sex:
Corresponding author’s e-mail: claudia.iegri@gmail.com • M (n- %) 16 (76%)
• F (n- %) 5 (23%)
Introduction: Currently, only few blood parameters are reported as predictive of liver Liver Disease:
failure post-TARE, such as bilirubin values greater than 2 mg/dl. • Cirhosis 20 (95%)
• Chronic hepatitis
1 (5%)
Aims: We aimed to assess a possible role of liver stiffness (LS) evaluated with ARFI, in Etiology
predicting post-TARE hepatic decompensation (HD) • Virus 13 (62%)
• Alcohol 5 (24%)
• Virus and alcohol 1 (5%)
Methodology: 39 consecutive patients were evaluated for TARE between April 2012 and • Others 2 (9%)
November 2013.Of these: 21 pts underwent SIRT, 11 pts (28.2 %) were excluded for
technical contraindications and/or disease severity and 7 pts (17.9 %) are still waiting for BCLC
the angiographic evaluation. Pre–treatment LS was available in 19 pts out of 21(90.4 %) • B (n- %) 15 (71%)
CLINICAL POSTER ABSTRACTS Median LS value was 16.6 kPa. Choosing it as a cut-off,we divided the population into Child-Pugh score (mean ± ds) 5.6 ± 0.7 CLINICAL POSTER ABSTRACTS
6 (29%)
• C (n- %)
Results: Baseline clinical characteristics of the population are summarized in Table 1.
Meld score (mean + ds)
8.3 ± 1.9
two groups: A (≥16.6 kPa;10 pts) and B (<16.6 kPa;9 pts). Age, CP score, MELD score
and BCLC stage were overlapping in the two subgroups. HCC size was lower in group
HCC type
A (72.1 ± 29 mm) than in group B (92 ± 58 mm), although not significantly. HD rate was
• Uninodular
2 (10%)
similar in the two groups (A: 40 % vs B: 44 %; p = ns), but the mean time to onset was
significantly longer in the latter (A: 19.5 ± 15.7 d vs B: 57.5 ± 25.7 d; P = 0.04). Per protocol
overall survival was 256.4 + 210 d; no differences were observed between the two groups • Multinodular 19 (90%)
HCC diameter (mean ± ds)
82 + 42 mm
(A:256.4±210 d vs B: 244.4±165 d; p = ns).
Conclusions: The shorter time to onset of HD after TARE in pts with lower LS suggest
a possible correlation between these variables that need to be confirmed expanding
population.