Page 257 - ebook HCC

GENEV
EASL HCC SUMMITHCC SUMMIT
PROGRAMME AND ABSTRACTSAND ABSTRACTS
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254 PROGRAMME GENEVA, SWITZERLANDA, SWITZERLAND EASL 255
FEBRUAR
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
Poster Board Number C38 Poster Board Number C39
A RCT TO COMPARE PRINGLE MANOEUVRE ALCOHOL, OBESITY AND TOBACCO AS RISK
WITH HEMI-HEPATIC VASCULAR INFLOW FACTORS FOR HEPATOCELLULAR CARCINOMA
OCCLUSION IN LIVER RESECTION FOR
HEPATOCELLULAR CARCINOMA WITH Adriana Babameto , Klerida Shehu , Edlira Ibro , Pranvera Kristani 4
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CIRRHOSIS 1 Gastroenterology & Hepatology, University of Technical Sciences, University Hospital
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Center “ Mother Theresa”, Gastroenterology & Hepatology, Specialistic Polyclinic,
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Junsheng Ni , Weiping Zhou , Joseph W. Lau 3 Tirana, Gastroenterology & Hepatology, Hospital of Durres, Durres, Albania
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1 The Third Department of Hepatic Surgery, The Third Department of Hepatic Surgery,
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai Corresponding author’s e-mail: ababameto2000@yahoo.com
200438, China, Shanghai, China, Faculty of Medicine, Prince of Wales Hospital, The
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Chinese University of Hong Kong, Shatin, Hong Kong, SAR, Hong Kong
Introduction: The role of alcohol as an important risk factor for hepatocellular carcinoma
Corresponding author’s e-mail: nijs77@gmail.com (HCC) has been described in different studies, while it is not the same for tobacco which
role as a risk factor for HCC is still discussed. Recently, some studies have reported also
obesity to be like a risk factor for HCC.
Introduction: The duration of hepatic vascular inflow occlusion and the amount of
intraoperative blood loss have significant negative impacts on postoperative morbidity, Aims: To evaluate the role of alcohol, tobacco and obesity as risk factors for HCC in
mortality, and long-term survival outcomes of patients who receive partial hepatectomy for Albanian patients.
hepatocellular carcinoma (HCC) with cirrhosis.
Methodology: Patients with HCC, cirrhosis with HCC and cirrhosis without HCC were
Aims: To compare the perioperative outcomes of partial hepatectomy for HCC enrolled in the study. We studied the role of alcohol and tobacco as well as obesity related
superimposed on hepatitis B-related cirrhosis using two different occlusion techniques. to the presence of HCC.
Methodology: A randomized controlled trial was carried out to evaluate the impact of two Results: In the study were enrolled 65 patients with HCC and 100 patients with cirrhosis
different vascular inflow occlusion techniques. The postoperative short-term results were without HCC. It was found significant correlation between alcohol, tobacco and obesity.
compared. Comparing HCC cases to the cirrhotic group without HCC, it was found that the risk of
CLINICAL POSTER ABSTRACTS cirrhosis. Of these patients, 120 patients were randomized equally into two groups: the dependent relationship between alcohol and tobacco exposure with risk of HCC was CLINICAL POSTER ABSTRACTS
HCC increased 4-fold for alcohol, 2-fold for tobacco and 2.5-fold with obesity. Also a dose-
Results: During the study period, 252 patients received partial hepatectomy for HCC with
noted.
Pringle manoeuvre group (n=60) and the hemi-hepatic vascular inflow occlusion group
(n=60). The number of patients who had poor liver function on postoperative day 5 (POD 5)
Conclusions: Alcohol, tobacco and obesity seem to be independent risk factors for HCC
with ISLGS Grade B or worse were 24, and 13, respectively (p=0.030). The postoperative
in our patients. They seem to be synergic factors increasing the risk of HCC. It shows to
complication rate was significantly higher in the Pringle manoeuvre group (40% versus
22%, p=0.30). However, the Pringle manoeuvre group had significantly shorter operating
time(116 mins versus 136 mins, p=0.012) although there was no significant difference in
intraoperative blood loss between the 2 groups [200ml (range 10-5000ml)] versus [300ml be a useful data for the surveillance of cirrhotic patients for HCC occurrence.
(range 100-1000ml)], (p=0.511). There was no perioperative mortality.

Conclusions: The results indicated that for patients with HCC with cirrhosis, hemi-hepatic
vascular inflow occlusion was a better inflow occlusion method than Pringle manoeuvre.