Page 282 - ebook HCC

PROGRAMME AND ABSTRACTSAND ABSTRACTS
280 PROGRAMME GENEVA, SWITZERLAND EASL HCC SUMMIT 281
280
FEBRUARY 13 - 16, 2014

Poster Board Number C55

ROLE OF 1H MR SPECTROSCOPY IN NOTES
EVALUATING RESPONSE OF HEPATOCELLULAR
CARCINOMA TO RADIOFREQUENCY ABLATION

Dina H. Ziada, Sherif Alsaadany, Manal Hamisa

Corresponding author’s e-mail: dhz646@hotmail.com

Introduction: The evaluation of the effectiveness of radiofrequency ablation is critical in
determining the success of hepatocellular carcinoma treatment .Studies have reported
an increase in choline-containing compounds relative to lipids in HCC compared with the
amounts found in background cirrhosis and a reduction in this ratio has been recorded
after effective local ablation treatment for HCC.
Aims: The aim of our work is to study the role of MR spectroscopy in evaluating the
response of hepatocellular carcinoma (HCC) to radiofrequency ablation.
Methodology: This study was carried out on 25 HCC patients eligible for RF ablation.
All patients underwent percutaneous RFA. Patient’s evaluations were done before RFA,
one, two and four weeks later, in the form of liver function tests, CBC, alfa fetoprotein
(AFP),abdominal triphasic C.T and 1H MR spectroscopy
Results: RFA was performed on 31 nodules of 25 patients. (AFP) was more than 200 in
18 patients. Post-RFA, AFP levels showed significant decrease in fourteen of them. The
choline resonance peak of HCC was elevated compared with normal liver parenchyma
CLINICAL POSTER ABSTRACTS which was significantly increased in HCC (0.421±0.021)(P=0.01 ). This ratio significantly CLINICAL POSTER ABSTRACTS
in the control group. After RFA both the amplitude and the area of choline resonance
peak significantly descended. The choline-to-lipid ratio was 0.334±0.023 in normal liver

decreased after RFA to 0.2360±.034 (P<0.001). The five patients who had incomplete
necrosis of HCC showed an elevated choline peak in the peripheral part of the tumor but
no elevation in choline peak in the central necrotic part of the tumor. A second intervention
effectively decreased the choline concentration in the peripheral part of the tumor
Conclusion: 1H MR spectroscopy is a useful tool for detection of early response of HCC
to RFA and can be valuable in differentiation between complete and incomplete necrosis
of the HCC lesions after RFA.