Page 284 - ebook HCC

GENEV
PROGRAMME
EASL HCC SUMMITHCC SUMMIT
282 PROGRAMME AND ABSTRACTSAND ABSTRACTS GENEVA, SWITZERLANDA, SWITZERLAND EASL 283
282
283
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
FEBRUAR
Poster Board Number C56
RISK OF HCC AND ITS PREDICTORS IN VIRAL
HEPATITIS COINFECTED PATIENTS

Kakharman I. Yesmembetov , Dzhamal T. Abdurakhmanov , Alexey N. Mukhin 1 According to logistic regression analysis, AFP was the only statistically significant predictor
1
1
1 Hepatology, I.M.Sechenov First Moscow State Medical University, Moscow, Russia of HCC (table 2).

Corresponding author’s e-mail: kyesmembetov@gmail.com Table 2. Predictor of HCC in group D
Predictor β Sig. Exp (B) (CI 95%)
Introduction: Worldwide, more than 350 million people are considered to have chronic AFP 0.030 0.042 1.031 (1.001-1.061)
HBV infection and 5%, 1%/7-15% of them are thought be coinfected with HDV and/or
HCV, due to shared routes of transmission.
1 (1.8%) patient (age 43, male) in group BC developed HCC during follow-up with mean
Aims: Studies, evaluating risk of HCC in HBV, HDV and/or HCV coinfected patients, duration of the disease when diagnosing HCC of 26.5 years. None of the predictors were
produced conflicting results. As coinfection with hepatitis viruses results in more severe able to statistically significantly predict risk for HCC.
liver disease, it may therefore carry a higher risk for HCC. We aimed to assess the risk for None of the patients in group BCD developed HCC during follow-up.
HCC and to identify its’ predictors in HBV, HDV and/or HCV coinfected patients. Group D, BC and BCD patients had 3.8%, 3.5% and 0% 5-year risk of HCC, respectively
(figure 1).
Methodology: HBsAg (+) patients with serum markers of HDV and/or HCV, followed-up
from Jan 2002 to Jan 2011 were included in the study.

Results: Out of 495 HBsAg (+) patients, 82 (16.6%), 56 (11.3%) and 20 (4%) patients
had markers of HDV (group D), HCV (group BC) and HCV/HDV (group BCD) coinfection,
respectively. Group BCD patients were significantly younger compared to other groups
and were predominantly male (table 1).
Table 1. General characteristics of patients
CLINICAL POSTER ABSTRACTS Mean age Group D Group BC Group BCD p 0.039 CLINICAL POSTER ABSTRACTS

33±9.4
42.4±15.4
40.7±13.8
0.005
50%
Male
90%
57.1%
no cases of HCC during follow-up, but demonstrated high rate of liver cirrhosis, despite
67.1%, 19.6% and 40% of patients in groups D, BC and BCD had liver cirrhosis, Conclusion: HDV infection was associated with the highest risk for HCC. Group BCD had
being significantly younger, thus given the same duration of the disease, they may present
respectively, demonstrating association of HDV with more pronounced liver injury and higher risk of HCC. Studies including more patients and with longer duration are needed
higher proportion of liver cirrhosis, compared to non-HDV patients. to further clarify this issue.
8 (9.8%) patients (mean age 50.8 years, male 50%) in group D developed HCC during
follow-up with mean duration of the disease when diagnosing HCC of 28±9.7 years.