Page 297 - ebook HCC

EASL HCC SUMMITHCC SUMMIT
GENEVA, SWITZERLANDA, SWITZERLAND
PROGRAMME
295
294 PROGRAMME AND ABSTRACTSAND ABSTRACTS GENEV EASL 295
294
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
FEBRUAR
Poster Board Number C63
SINGLE CENTER EXPERIENCE OVER A DECADE
IN LIVING DONOR LIVER TRANSPLANTATION
FOR EGYPTIAN PATIENTS WITH
HEPATOCELLULAR CARCINOMA: STRETCHING
THE LIMITS

Iman Montasser , Mahmoud El Meteini , Hany Dabbous , Mohammed Sakr Results: The median follow up period was 31.6 months. The underlying liver disease
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1
1
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and Ain Shams Center For Organ Transplantation (ASCOT) was related to HCV in 139 cases (95.2%).Ninety-five patients (65%) were fulfilling Milan
1 Ain Shams University, Cairo, Egypt criteria, 40 patients (27.5 %) were within University of California San Francisco criteria
(UCSF) and 11patients (7.5%) were beyond; maximum tumor burden 14.5 cm in one.
Corresponding author’s e-mail: imanfawzy@gmail.com One hundred and thirty four (91.8%) are alive till April 2012, 127 (87%) being recurrence
free .HCC recurrence occurred in 19 patients (13%), 12 patients were within Milan criteria
and 7 were beyond Milan. Within patients beyond UCSF; one case had HCC recurrence.
Introduction: Liver transplantation emerged as rewarding therapy to cure hepatocellular Microvascular invasion and AFP > 400 were significant prognostic factors for recurrence.
carcinoma (HCC). Extensions of Milan criteria have been proposed with encouraging
results. The development of HCC is mainly due to the high rate of C infection among Conclusion: Within community with high incidence of HCC, stretching the limits could be
Egyptian patients .Living donor liver transplantation (LDLT) for HCC in cirrhotic patients justified based on tumor characters and its biological behavior
has emerged as a rewarding therapy for a cure and a successful alternative especially in
countries where a DDLT program is lacking.

Aims: The aim of this work was to determine the different prognostic factors for HCC after
LDLT. Survival of the patients was recorded.

Methodology: Methods: 590 Egyptian patients underwent LDLT; of them, 172 (32%)
patients were transplanted for HCC. Twenty six cases (15.1%) were excluded due to early
CLINICAL POSTER ABSTRACTS Data were collected, coded, tabulated, and analyzed using SPSS®v12.0. Numerical CLINICAL POSTER ABSTRACTS
postoperative mortality (n=22) or due to non HCC related mortality (n=4). One hundred forty
six patients were retrospectively reviewed to determine prognostic factors for recurrence.

variables were presented as mean (standard deviation) or median (range) as appropriate,
while categorical variables were presented as frequency (%).Analysis of categorical data
was performed by chi-square test or Fisher’s exact test while that of numerical variables
was performed by student-t test. Kaplan-Meier survival analysis was performed for the
significant risk factors of recurrent HCC with application of log rank test to compare levels
of each factor. P value < 0.05 was considered statistically significant.