Page 299 - ebook HCC

PROGRAMME AND ABSTRACTSAND ABSTRACTS
EASL
GENEV
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296 PROGRAMME GENEVA, SWITZERLANDA, SWITZERLAND EASL HCC SUMMITHCC SUMMIT 297
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
FEBRUAR
Poster Board Number C64 Poster Board Number C65
ANATOMO-CLINICAL ASPECTS OF DELTA HEPATITIS-RELATED HEPATOCELLULAR
HEPATOCELLULAR CARCINOMA IN ALGERIA : CARCINOMA: NEW MESSAGES FROM EASTERN
MONOCENTRIC STUDY OF 280 CASES FRONT

Ahmet C. Dulger, Rafet Mete , M. Kürşat Türkdogan ,
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Yazid Chikhi , Saadi Berkane , Salima Cheraitia , Nassima Ali Arous , Senar Ebinç 1 2 3 , Hüseyin Akdeniz 1 2 3 4
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Rachid Ould Gougam , Omar Louahadj , Fadela lounes , Meroua Bendaoud , 1 Namik Kemal University School of Medicine, Tekirdag, Gastroenterology, Bezmi
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Razika Zemba , Sonia Ait Younes , Zine Charef Amir , Chareazed Sufan , Alem University Faculty of Medicine, İstanbul, Gastroenterology, Yuzuncuyil University
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Fatima Asselah , Hocine Asselah 2 Medical School Turkey, Radiology, İstanbul Hospital, Van, Turkey
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Corresponding author’s e-mail: acdulger@gmail.com
Corresponding author’s e-mail: cyazid2002@yahoo.fr
Introduction: Hepatitis delta virus (HDV) is a small, defective and single -strand RNA
genome contained virus. It has been responsible nearly 25% of hepatocellular carcinoma
Introduction: Hepatocellular carcinoma develops mainly in liver cirrhosis. In Algeria, (HCC) cases in eastern part of Turkey.
cirrhosis is associated with a chronic viral infection B or C in 90% of cases. The prevalence
of HBsAg is about 2.15% and that of HCV infection at least 1%. Aims: So, this study was conducted to determine the clinical and radiologic aspects of
delta hepatitis-related HCC in the Van region of Eastern Turkey. The aim was also to
define the association between laboratory parameters and radiologic features.
Aims: The aim of our study was to determine the epidemiological, etiological CHC to
provide an optimal care. Methodology: Current study was conducted from 2006 to 2013 in Hepatology clinic of the
Yuzuncuyil University School of Medicine. 35 patients (15 female, age 58.3± 10.8) with
Methodology: From January 1988 to december 2012, 280 HCC were collected, this study HDV-related HCC were included for the study. Diagnosis of HCC was made by biopsy
distinguishes two periods: before 2009 a retrospective study (n = 120) and prospectively (avaible in 30) or by clinical data plus radiologic examination. Demographics, Child-Pugh
scores, laboratory values including tumor markers were noted. Serological markers of
from 2009 to December 2012 (n = 160). The diagnosis of HCC was selected according to hepatitis D virus infection (antiHDV IgG) were also determined by ELISA test in patients
the criteria of Barcelona. with chronic hepatitis B patients. Thereafter, radiologic findings including diameters of
portal and splenic vein as well as largest diameter of tumor mass were studied. Pearson
Results: Collected on 280 cases, 182 men and 98 women (sex ratio 2.4), the average correlation analysis was used to determine the relationship between parameters.
CLINICAL POSTER ABSTRACTS a screening ultrasound in 9.6% of cases during the period before 2009 and 21% after At baseline, elevated levels of AST (107±74,68), ALT (65,26±45,88), AFP (180,47 CLINICAL POSTER ABSTRACTS
age is 61 years. The diagnosis is revealed by pain in the right hypochondrium (39%),
Results: Twenty-five patients (71.4%) were resident in rural areas of the Van prefecture.
impaired general condition (37%), liver tumor (31%), jaundice (7.3%). It is revealed by
±177,12) GGT (170,10±121,86) and CRP (37,04±39,77) are the main laboratory features
2009. Underlying cirrhosis was found in 71% of cases, chronic liver disease in 15% and
among the patients. Detoriation of liver dysfunction as reflected by the higher CTP scores
a healthy liver 7% of cases. B and C viruses are implicated in 21% and 39% respectively.
(7,87±2,26 points) was also a common finding in the study group. Additionally, patients
Our CHC were in most cases stages C and D (BCLC classification). The treatment
were likely to have larger tumor masses (7,41 ± 4,76 cm). Diameters of portal and splenic
consisted of liver transplantation (n = 1), hepatic resection (n = 27), alcohol / radio
There was no statistical differences between genders (p>0.05). Most importantly, levels of
frequency (n = 8), chemoembolization (n = 26) sorafenib (n = 12). The median survival of
AFP were positively correlated with portal vein diameters (p<0.01). Furthermore, elevated
12 months was 13%. veins were also larger than normal values (16,33± 4,93 and 12,69 ±5,43, respectively).
leves of CRP were also positively correlated with CA-19.9 levels (p<0.01).
Conclusion: This study reveals the late diagnosis of HCC, the time has changed little Conclusion: Our hospital’s experience documents that the percentage of patients who
despite the application of screening recommendations and the necessity of a national may be considered as liver transplantation candidates is still very low. Rural clustering
program to fight against viral hepatitis. of the new cases was a striking finding in the current study. Higher AFP levels may also
predict the presence of enlargement of portal vein in patients with HDV-related HCC.