Page 303 - ebook HCC

EASL
PROGRAMME AND ABSTRACTSAND ABSTRACTS
GENEV
300 PROGRAMME GENEVA, SWITZERLANDA, SWITZERLAND EASL HCC SUMMITHCC SUMMIT 301
301
300
FEBRUARY 13 - 16, 2014Y 13 - 16, 2014
FEBRUAR
Poster Board Number C68
HCC EPIDEMIOLOGY

Francesca Romana Ponziani , Maria Assunta Zocco , Matteo Garcovich ,
2
2
1
Emanuele Rinninella , Antonio Gasbarrini and the HEPATOCAT All HBV HCV P value
2
multidisciplinary group for the treatment of HCC Gender (Male/ 203/63 58/16 145/47 0.623
1 Internal Medicine and Gastroenterology, A Gemelli Hospital, Rome, Italy Female)
2
Age (mean ± SD) 66 ± 10 62 ± 11 68 ± 10 <0.001
Corresponding author’s e-mail: francesca.ponziani@yahoo.it <=40 years 4/257 (1.5%) 3/71 (4.2%) 1/186 (0.5%) 0.013
40-60 years 59/257 (21.8%) 22/71 (31%) 37/186 (20%)
Introduction: Hepatocellular Carcinoma (HCC) is one of the most common complications >60 194/257 (75.5%) 46/71 (65%) 148/186 (79.5%)
of HCV and HBV-related liver disease. Young age, large and multinodular HCCs are typical cirrhosis 261/266 (98%) 71/74 (96%) 190/192 (99%)
of HBV patients, which accounts for 50% of the cases, while the presence of cirrhosis is CHILD A/B/C 181/57/16/7 45/20/4/2 136/37/12/5 0.506
the most common characteristic in HCV ones.
AFP (mean ± SD) 1479 ± 450 2676 ± 10200 996 ± 4697 0.091
Aims: To report the epidemiology and features of HCC in an Italian single center comparing <=20 113/226 (50%) 34/65 (52%) 79/161 (49%) 0.462
HBV and HCV patients. 21-200 66/226 (30.5%) 15/65 (23%) 51/161 (32%)
201-1000 21/226 (9%) 6/65 (9%) 15/161 (9%)
Methodology: 266 Caucasian cirrhotic patients with HCV or HBV cirrhosis or chronic
hepatitis were selected from the prospective database of the HEPATOCAT multidisciplinary >1000 26/226 (11%) 10/65 (15%) 16/161 (10%)
group for the treatment of HCC. Patients with non HCC tumors were excluded from the BCLC 0/A/B/C/D 35/118/58/34/21 6/32/21/10/5 29/86/37/24/16 0.372
analysis. Age, sex, BCLC, number and size of lesions, Child-Pugh score when applicable, Single lesion 143/266 (54%) 39/74 (53%) 104/192 (54%) 0.830
vascular invasion and metastasis were evaluated. Chi-square and Student’s t-tests were Multinodular 123/266 (46%) 35/74 (47%) 88/192 (46%)
used to compare data; a two-sided P value of 0.05 was considered statistically significant.
Tumor <5 cm 209/263 (79.5%) 50/74 (67.5%) 159/189 (84%) 0.003
Results: Patients’ characteristics are shown in Table 1. 192 (72.2%) patients were HBV Tumor >5 cm 54/263 (20.5%) 24/74 (32.5%) 30/189 (16%)
infected AND 74 PATIENTS (27.8%) hcv infected. HBV-related liver disease seems Macrovascular 35/266 (13%) 13/74 (17.5%) 22/192 (11.5%) 0.079
CLINICAL POSTER ABSTRACTS invasion. Furthermore, metastases were more common among patients with HBV infection Conclusion: In our series of Italian patients, HBV-related HCC is more common in young CLINICAL POSTER ABSTRACTS
invasion
associated to a younger age (p<0.001) and larger HCCs (p=0.005) than HCV, while
7/74 (9.5%)
4/192 (21%)
0.007
11/266 (4%)
no difference was found in degree of liver dysfunction, number of lesions and vascular
Metastases
(p=0.007).
people and more aggressive than HCV-related one, since it presents with lesions of larger
size and more prone to develop metastases.