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loud, demanding, foreign. And the immune system does
what any overwhelmed student might do: it shuts down the
lesson. Or worse, it retaliates.

What if, instead of shouting at the immune system, we
taught it? What if biologics could be introduced in ways
that encourage recognition, not rejection?

A New Class of Biologics—Built for
Compatibility

The future of biologics doesn’t lie in brute force. It lies in
biologic humility—in therapies that integrate with the
immune system, rather than evade it. Therapies that aren’t
just effective on day one, but remain effective year after
year.

This next generation of biologics is already emerging—
quietly, experimentally, and with game-changing potential.
These aren’t just tweaks to the status quo. They represent a
wholesale shift in philosophy: from suppression to
cooperation. From potency to persistence.

This includes:

• Oral biologics that harness the gut’s built-in
tolerance mechanisms, allowing the immune system
to process therapeutic proteins in the same way it
learns to tolerate food antigens and commensal
microbes.
• Plant-based expression systems that produce
cleaner proteins with fewer immunogenic
impurities—eliminating contamination and

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