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A drug isn’t successful if it can’t stay.

The next generation of biologics will be:

• Less about the binding curve and more about the
body’s tolerance.
• Less about symptom suppression and more about
immune stability.
• Less about biochemical tricks and more about
biological relationships.

Because in the end, this isn’t just a rebellion against
tolerization. It’s a revolution in expectations.

8.4 – A New Contract: Industry, Immune System,
and Humanity

For decades, the biologics industry has operated under a
tacit contract: we develop powerful therapies, patients
accept the side effects and uncertainty, and everyone agrees
to rotate drugs when they fail. That contract was built on an
era of scarcity—when innovation meant simply having
something to offer.

But now we know more. We know that the immune system
doesn’t just forget. It learns. It resists. And when it rejects a
biologic, it’s often for good. We also know that rotating
therapies isn't a sign of success—it's a signal of structural
failure. And most damning of all: we know it doesn’t have
to be this way.

It’s time for a new contract. One that respects the immune
system not as a threat, but as a partner. One that prioritizes
the long-term relationship between therapy and biology,

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