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Table of Contents
Introduction: The Biologic Boom’s Dirty Secret
• The rise of biologic drugs—miraculous, expensive,
and increasingly common.
• No one talks about immune tolerization and
neutralizing antibodies.
• Why solving this problem could unlock the next
generation of medicine.
Chapter 1: The Tolerization Time Bomb
• What tolerization is and how it quietly undermines
drug efficacy.
• Case studies: Humira, Enbrel, Factor VIII—when
the miracles wear off.
• The staggering cost: to patients, payers, and
pharma’s bottom line.
Chapter 2: How We Got Here
• The race to commercialize injectable biologics.
• Why biologic drugs weren't built to last: short-term
fixes vs long-term immune harmony.
• The failure of current strategies
(immunosuppressants, drug rotation, dose
escalation).
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