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Introduction: The Cure That Fades
Biologic drugs changed medicine. But now, the body is
fighting back—and we’re running out of time to respond.
In just two decades, biologic drugs have become the crown
jewels of modern medicine. These aren’t ordinary drugs.
They’re living molecules—antibodies, enzymes, hormones,
and cell therapies—engineered in living cells to modulate
the immune system with extraordinary precision.
They’ve done what pills never could:
• Target an autoimmune disease.
• Unleash white blood cells to fight cancer.
• Replace molecules the body never learned to make.
Biologics don’t just treat diseases, they regulate, replace,
inhibit, and retrain. For millions, they’ve brought life-
changing relief.
But hidden behind their success is a growing crisis.
The very immune system these drugs are meant to help…
are starting to reject them.
It’s called tolerization—when the body recognizes a
biologic drug as foreign and builds antibodies to block it.
The clinical term is immunogenicity. But for patients, it
feels like betrayal. The drug that worked so well just…
stops.
Symptoms are returning. Inflammation flares. And
treatment plans collapse.
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