Page 29 - YORAM RUDY BOOK FINAL

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(Left) Figure 2.14. Undiseased human
endocardial AP traces from experiments
(small tissue preparations) and model
simulations. A. Simulated APs for a range
of pacing frequencies (top) and
corresponding examples of experimentally
recorded APs (below). Arrows indicate cycle
length (CL) changes. B. Comparison of
simulation (black) and experimentally
measured (gray) basic AP parameters for
a single paced beat from quiescence (N=32
for 32 hearts). Shown, from top to bottom,
are the resting membrane potential
(V rest ), maximum upstroke potential
m
(V max) and maximum upstroke velocity
m
(dV /dt max). From O’Hara et. al. [18].
m
Reproduced under PLOS ONE Creative
Commons Attribution (CC BY) license.

(Right) Figure 2.15. Rate de-
pendence of currents at steady
state. Arrows indicate CL de-
crease (rate increase). Top row:
simulated APs, repeated in each
column for timing purposes.
Lower rows: currents during
the AP; the arrows indicate
direction of rate increase. Insets
show expanded scale of peak
I and peak I CaL . I inset shows
to
Na
late small window current. I
Kr
inset shows early spiking at fast
rates.. From O’Hara et. al. [18].
Reproduced under PLOS ONE
Creative Commons Attribution
(CC BY) license.