Page 75 - YORAM RUDY BOOK FINAL

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Figure 3.2. Experimentally recorded AP propagation in a synthetic strand of neonatal rate
myocytes during greatly reduced gap-junction coupling. A. Micrograph of a strand segment;
Circles mark positions of light measuring diodes for optical recording of the AP. B. Recorded AP
upstrokes cluster in groups, with almost simultaneous excitation within each group and
propagation delays of up to 5 msec between groups. C. Groups of almost simultaneous APs
are indicated by numbers on the strand cellular morphology showing cell borders (gray lines).
Comparison of B and C shows that conduction delays between groups are confined to cell
borders. There is also complete conduction block in the cell marked by rectangular hatching.
Adapted from Rohr, Kucera and Kléber [178], with permission from the authors and Wolters
Kluwer Health, Inc.