Page 96 - YORAM RUDY BOOK FINAL

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Figure 3.15. Schematic
representation of the
vulnerable window for
unidirectional block during
the refractory period of a
propagating AP. TW, SW
and VW represent the
vulnerable window in
the time domain, space
domain, and voltage
domain, respectively. From
Rudy [225] with permission
from John Wiley and Sons.

Figure 3.16. Properties of
propagation induced by
a premature stimulus in
the vulnerable window.
Antegrade decremental
propagation (right) and
retrograde incremental
propagation (left) is
induced. A and B: AP (V ).
m
C and D: g , sodium
Na
conductance that
determines membrane
excitability. These para-
meters are displayed at
increasing distances
(curves 1-5) from the site of
premature stimulation in
both directions. Note
different g scales in left
Na
and right panels. Adapted
from Quan and Rudy [222],
with permission from
Wolters Kluwer Health, Inc.