Page 99 - slide_napoli_CKD_giovedi

RADAR; Endothelin A Antagonist reduces albuminuria reduction in type 2 diabetes on top of optimal ACEi/ARB
20
0 Placebo -20
60
40
Placebo
0.75 mg Atrasentan 1.25 mg Atrasentan
51%55%
**
37% * 35%
42%
*
*
-40 -60
0.75 mg atrasentan
1.25 mg atrasentan
20
13%
28% * 2%
6%
0 2 4 6 8 10 12 30
0
30% 40% 50%
Time, Weeks
-Days off
UACR reduction
De Zeeuw et al; JASN 2014
% Geometric Mean Change
% of Subjects