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HEALTHWednesday 10 January 2018

Usage remains low for pill that can prevent HIV infection

By DAVID CRARY                  In this May 10, 2012 file photo, a doctor holds Truvada pills at her office in San Francisco. The pill                                bination with other drugs
AP National Writer              has been shown to reduce the risk of getting HIV from sex by more than 90 percent if taken daily.                                     as the basic treatment for
NEW YORK (AP) — From                                                                                                                                                  people who have HIV, the
gritty neighborhoods in                                                                                                                             Associated Press  virus that causes AIDS. It is
New York and Los Angeles                                                                                                                                              primarily spread through
to clinics in Kenya and Bra-    language” — launched a        lakis, a deputy commis-         Under federal guidelines,                                               sex.
zil, health workers are trying  campaign to increase use      sioner of the city’s health     prime candidates for pre-                                               Controversy arose in 2012
to popularize a pill that has   among young Latino and        department.                     ventive use of Truvada in-                                              when the U.S. Food and
proven highly effective in      black gay men and trans-      However, Daskalakis said        clude some gay and bisex-                                               Drug Administration ap-
preventing HIV but which        gender women.                 use among young black           ual men with multiple sex-                                              proved Truvada to reduce
— in their view — remains       “We’ve got the tools to not   and Hispanic men — who          ual partners, and anyone                                                the risk of getting HIV in
woefully underused.Mar-         only end the fear of HIV,     account for a majority of       who does not have HIV                                                   the first place, for what’s
keted in the United States      but to end it as an epidem-   new HIV diagnoses — lags        but has an ongoing sexual                                               called pre-exposure pro-
as Truvada, and sometimes       ic,” said the center’s chief  behind. To address that,        relationship with someone                                               phylaxis, or PrEP. It blocks
available abroad in ge-         of staff, Darrel Cummings.    the city is making Truvada      who has the virus.                                                      the virus from making cop-
neric versions, the pill has    “Those at risk have to know   readily available in some       Abroad, a few govern-                                                   ies and taking hold. Critics
been shown to reduce the        about the tools, though,      clinics in or near heavily      ment health agencies —                                                  warned that many gay
risk of getting HIV from sex    and they need honest in-      black and Hispanic neigh-       including those in France,                                              men wouldn’t heed Tru-
by more than 90 percent         formation about them.”        borhoods.                       Norway, Belgium, Kenya,                                                 vada’s once-a-day sched-
if taken daily. Yet world-      In New York, roughly 30       “We like to go to the root      South Africa, Brazil and                                                ule and complained of its
wide, only about a dozen        percent of gay and bisex-     of the problem,” said Das-      some Canadian prov-                                                     high cost — roughly $1,500
countries have aggressive,      ual men are using Truvada     kalakis, who personally         inces— have launched                                                    a month.
government-backed pro-          now, up dramatically from     posed for the “Bare It All”     major efforts to promote                                                Gilead offers a payment
grams to promote the pill.      a few years ago, accord-      campaign.                       preventive use of Truvada                                               assistance plan to people
In the U.S., there are prob-    ing to Dr. Demetre Daska-     According to the U.S. Cen-      or generic alternatives,                                                without insurance that cov-
lems related to Truvada’s                                     ters for Disease Control and    providing it for free or a                                              ers the full cost. Some cities
high cost, lingering skepti-                                  Prevention , Truvada would      nominal charge. In Britain,                                             and a few states — includ-
cism among some doc-                                          be appropriate for about        health officials in Scotland                                            ing Illinois, Massachusetts
tors and low usage rates                                      1.2 million people in the U.S.  and England recently took                                               and Washington — also
among black gays and bi-                                      — including sex workers         steps to provide the medi-                                              help cover costs. Activists
sexuals who have the high-                                    and roughly 25 percent of       cation directly through                                                 have pressed Gilead to
est rates of HIV infection.                                   gay men. Gilead Scientific,     government-funded pro-                                                  make its copay program
“Truvada works,” said                                         Truvada’s California-based      grams, though in England                                                more generous in light of its
James Krellenstein, a New                                     manufacturer, says there        it’s in the form of a trial lim-                                        profits from Truvada.
York-based activist. “We                                      are only about 145,000 ac-      ited to 10,000 people.                                                  “There’s no reason it has to
have to start thinking of                                     tive prescriptions for HIV      Truvada was launched in                                                 cost so much,” said Krellen-
it not as a luxury but as                                     prevention use.                 2004, initially used in com-                                            stein.
an essential public health                                                                                                                                            Gilead spokesman Ryan
component of this nation’s                                                                                                                                            McKeel, in an email, said
response to HIV.”                                                                                                                                                     the company is reviewing
A few large U.S. cities are                                                                                                                                           the copay program.
promoting Truvada, often                                                                                                                                              “Like those in the advo-
with sexually charged ads.                                                                                                                                            cacy community, we are
In New York, “Bare It All”                                                                                                                                            committed to expanding
was among the slogans                                                                                                                                                 access to Truvada for PrEP
urging gay men to consult                                                                                                                                             to as many people as pos-
their doctors. The Los An-                                                                                                                                            sible,” he wrote.
geles LGBT Center — using                                                                                                                                             In June, the FDA approved
what it called “raw, real                                                                                                                                             a generic version of Tru-
                                                                                                                                                                      vada, which is likely to
                                                                                                                                                                      push the price down, but
                                                                                                                                                                      it won’t be available in the
                                                                                                                                                                      U.S. for a few years.
                                                                                                                                                                      The Truvada debate has
                                                                                                                                                                      taken many twists, as ex-
                                                                                                                                                                      emplified by the varying
                                                                                                                                                                      stances of the Los Angeles-
                                                                                                                                                                      based AIDS Healthcare
                                                                                                                                                                      Foundation — a leading
                                                                                                                                                                      HIV/AIDS service
                                                                                                                                                                      provider. q
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