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A28    SCIENCE
                        Friday 13 July 2018

            Late-life high blood pressure may harm the brain, study says


            By MARILYNN MARCHIONE                                                                  once  a  year  during  the  to understand the implica-
             AP Chief Medical Writer                                                               study  —  a  strength  of  this  tions, Arvanitakis said.
            Decades  ago,  hundreds                                                                work  over  some  previous  "It's  a  pretty  strong  study,"
            of  nuns  and  priests  made                                                           research that just relied on  said  James  Hendrix,  direc-
            an  extraordinary  decision:                                                           people to say whether they  tor of global science initia-
            They  agreed  to  donate                                                               had high pressure or not.    tives  at  the  Alzheimer's  As-
            their  brains  upon  death  to                                                         After   each   participant  sociation.  "Autopsy  data
            science,  hoping  to  help                                                             died,  researchers  exam-    is  really  powerful"  and  has
            solve  mysteries  about  Al-                                                           ined  their  brains  for  areas  been the gold standard for
            zheimer's and other diseas-                                                            of  dead  tissue  caused  by  diagnosing  Alzheimer's  for
            es. Now, a study that used                                                             lack of blood supply. These  many years, he said.
            their  gifts  is  giving  some                                                         blighted areas can be tiny  With  Alzheimer's,  changes
            clues.  It  reveals  that  high                                                        and  cause  no  symptoms,  in  the  brain  occur  a  de-
            blood  pressure  late  in  life                                                        so they're sometimes called  cade or more before symp-
            might harm the brain.                                                                  evidence of "silent strokes."  toms  do,  so  high  blood
            Autopsies  on  nearly  1,300                                                           About  half  of  the  study  pressure  may  have  been
            older  people,  including                                                              participants  had  one  or  doing damage well before
            about  640  clergy  mem-                                                               more of these, and the risk  the  age  when  these  peo-
            bers,  found  more  signs  of   This Oct. 7, 2003 file photo shows a closeup of a human brain   was  greater  for  those  with  ple enrolled in the study, he
            damage  and  one  of  the    affected by Alzheimer's disease on display at the Museum of   higher  blood  pressure.  For  said.
            hallmarks of Alzheimer's dis-  Neuroanatomy at the University at Buffalo in Buffalo, N.Y.   example,  people  with  an  How might high pressure do
                                                                                  Associated Press
            ease in the brains of those                                                            average top reading of 147  harm?
            with  higher  blood  pres-   "We  can't  be  alarmist.  This  the  Religious  Orders  Study  had  a  46  percent  greater  "Lower  blood  pressure  re-
            sure  than  among  those  is  preliminary  data"  that  of Catholic clergy through-    risk of having one or more  duces  the  risk  of  those
            with pressure closer to nor-  needs  to  be  validated  out the United States.         of the bad spots than those  blood  vessel  blockages"
            mal,  researchers  reported  by  others,  said  the  study  All were over 65 and with-  with an average top read-   that  can  cause  a  silent
            Wednesday.                   leader,  Dr.  Zoe  Arvanitakis  out known dementia at the  ing of 134.                 stroke,  said  another  inde-
            The  study  does  not  prove  of  Rush  University  Medical  start and were followed un-  People with higher bottom  pendent expert, the Mayo
            cause  and  effect,  and  it  Center  in  Chicago.  "It's  far  til they died — at an aver-  blood  pressure  readings  Clinic's Dr. David Knopman.
            does  not  yet  provide  a  too  soon  to  make  recom-   age age of 89 and after an  also  had  a  greater  risk  for  The work shows that "treat-
            comparison of rates of de-   mendations  about  blood  average  of  eight  years  in  this problem.                 ing blood pressure through-
            mentia or its most common  pressure  in  older  people  the study.                     Researchers  also  found  a  out  the  lifespan  is  impor-
            form,  Alzheimer's  —  those  based on this study."       Two-thirds  had  high  blood  link  between  higher  pres-  tant."
            results  will  take  longer  to  The research began in 1994  pressure,  defined  as  a  top  sure  and  one  of  the  signs  Knopman  is  a  spokesman
            parse.  But  it  challenges  a  and   combined   people  reading  of  140  or  more  of Alzheimer's — tangles of  for the American Academy
            theory that high pressure is  from  three  studies  of  ag-  when the study began (it's  a protein called tau — but  of  Neurology,  whose  jour-
            not  as  harmful  in  old  age  ing who agreed to donate  now 130 under new guide-     not  another  Alzheimer's  nal,  Neurology,  published
            as  it  is  when  people  are  their  brains  for  autopsy  lines adopted last fall.) Their  hallmark, amyloid plaques.  the  study.  Federal  grants
            younger.                     upon their death, including  pressures  were  measured  This needs further research  paid for the work.q

                                                                      Ancient 'Iceman' shows signs


                                                                      of a well-balanced last meal



                                                                      By  EMILIANO  RODRIGUEZ  searchers said.                  medicine for parasites pre-
                                                                      MEGA                         On  the  menu,  described  viously found in his gut.
                                                                      Associated Press             Thursday in the journal Cur-  "It was very impressive," said
                                                                      NEW  YORK  (AP)  —  Talk  rent  Biology,  were  the  fat  lead author Frank Maixner,
                                                                      about a paleo diet. Scien-   and  meat  of  a  wild  goat,  a  microbiologist  at  the  In-
                                                                      tists  have  uncovered  the  meat  of  a  red  deer  and  stitute  for  Mummy  Studies
                                                                      last meal of a frozen hunter  whole wheat seeds, which  in Bolzano, Italy. "We could
                                                                      who  died  5,300  years  ago  Oetzi ate shortly before his  see  chunks  and  pieces  of
                                                                      in the Alps.                 death.                       food with (the) naked eye."
                                                                      The  stomach  contents  of  Traces  of  fern  leaves  and  Though  the  researchers
                                                                      the  corpse,  widely  known  spores  were  also  discov-  had  previously  examined
             In  this  November  2010  photo  provided  by  the  South  Tyrol  as  Oetzi  the  Iceman,  of-  ered  in  Oetzi's  stomach.  Oetzi's  intestines,  this  was
             Museum of Archaeology, researchers examine the body of a   fer a snapshot of what an-  Scientists  think  he  may  the  first  time  they  could
             frozen hunter known as Oetzi the Iceman to sample his stomach   cient  Europeans  ate  more  have  swallowed  the  plant  look  into  his  stomach.The
             contents in Bolzano, Italy.
                                                     Associated Press   than five millennia ago, re-  unintentionally  or  as  a  reason  is  nothing  short  of
                                                                                                                                grotesque.Following Oetzi's
                                                                                                                                death,  the  organ  moved
                                                                                                                                upwards.  It  was  not  un-
                                                                                                                                til  2009,  18  years  after  his
                                                                                                                                remains  were  discovered
                                                                                                                                near  the  Italy-Austria  bor-
                                                                                                                                der,  that  a  radiologist  de-
                                                                                                                                tected  it  behind  the  rib
                                                                                                                                cage. And it was full. After
                                                                                                                                slowly defrosting the body,
                                                                                                                                the team took samples and
                                                                                                                                rehydrated them.q
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