Page 60 - Demo 1

Figure 31. Signs and Symptoms of Progeria
Source: http://www.dovemed.com/uploads/images/Symptoms_of_Progeria_5vTfmdu.max-1000x800.png

Effects on Organelles
Supersession of the mitoc checkpoints in cancer cells causes runaway damage
to the cell's organelles, which are units within the cells that carry out specific
funcons. During normal mitosis, damaged organelles have a chance to repair
and recover between cell divisions, but they don't have this opportunity when
cell division doesn't stop. Cells with damaged organelles can die. Leakage from
damaged mitochondria, which are organelles that provide energy to the cell,
can trigger the release of "execuoner" enzymes.

Mosaicism

Cell mutaons within an individual are not always uniform; some cells may have
a mutant version of a gene while others have the normal version of the same
gene. Genecists refer to this condion as mosaicism. In somac cells, or cells
other than egg or sperm cells, the individual may not be affected by the
mutaons, but if the mutant genotype is widespread and harmful enough, the

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