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Technical Aspects of Fluid Therapy  373


            If the animal is prone to peripheral edema, a limb bandage  obstruction with a clot. Continuous infusion of central
            may be extended distally to the paw. However, this is not  venous and arterial catheters with solutions containing
            routinely necessary in an ambulatory animal with a prop-  1 U/mL of heparin prolongs the life of those catheters
            erly applied catheter bandage. A heavy full limb bandage  in human patients. 17,38,67  In contrast, the value of inter-
            may be used (with or without a rigid splint) if the indwell-  mittent flushing of catheters with heparin solutions is less
            ing catheter crosses a joint. Immobilization of the joint in  clear, with some recent studies showing that use of hepa-
            this setting helps reduce endothelial trauma and may help  rinized saline prolongs catheter patency and others
            prevent venous thrombosis secondary to mechanical   showing no benefit from intermittent heparin solutions
            injury by the catheter.                             compared with saline alone. 54,66,67  These discrepancies
                                                                may be partly because of study differences in training
            CATHETER MAINTENANCE                                nursing staff to properly flush catheters (Figure 15-8)
                                                                or disparities in data analysis. 71  No objective studies have
            The need for an intravenous catheter should be reviewed  addressed this issue in veterinary patients. Based on
            daily and the catheter removed when it is no longer ther-  human practice and observations of veterinary patients,
            apeutically necessary. Until then, the vein and the limb or  catheters that are not being used may be filled once daily
            face should be examined at least twice daily for evidence  with concentrated heparin (100 to 1000 U/mL).
            of infection or edema. Regional lymph nodes should be  Catheters used only for intermittent administration of
            palpated for signs of swelling or tenderness. If any  drugs should be flushed with sterile saline (with or
            evidence of inflammation or thrombosis is found, the  without heparin) and locked with a more concentrated
            catheter should be removed. If the bandage is too tight,  heparin solution immediately after drug administration.
            it should be loosened or completely replaced. When distal  Frequent flushing with higher concentrations of heparin
            edema is evident, the culprit is usually white tape that was  in  cats  and  small  dogs  may  produce  systemic
            applied too tightly.                                anticoagulation and should be avoided.
              Although increasing duration of catheterization does  Sterility of the infusion system must be maintained.
            not necessarily increase the rate of bacterial coloniza-  Only new  sterile  administration  sets  should  be
            tion, 47,48  catheters (especially over-the-needle designs)  attached to a new catheter (unless it is used for just a
            should be routinely considered for removal by 72 to 96  few hours [e.g., for intraoperative fluid therapy]), and
            hours, especially if there is palpable evidence of thrombo-  disconnections are made only when essential. Hands
            sis or phlebitis. The dressing covering a through-the-nee-  should be washed and disposable gloves worn for setting
            dle catheter should be routinely replaced at 48 hours or  up a new system, making disconnections, injecting
            more frequently if it appears wet or soiled. At this time,  medications, or withdrawing blood. When fluids are to
            the skin and vein are examined and palpated for evidence  be administered, a “T” piece or needleless connection
            of inflammation or thrombosis. If either is suspected  device should be used at the catheter, and locking Luer
            consider removing the catheter. If the catheter and vein  connections should be used between the administration
            appear in good condition, the skin surrounding the entry  set, extension sets (if used), and the patient catheter.
            site is cleansed with an antiseptic scrub and cotton balls.  Needleless connection devices that allow blood with-
            Disruption of the entry wound or any in-and-out     drawal, intravenous administration set disconnections,
            movement of the catheter through the wound is avoided.  and drug administration minimize contamination of
            The skin is allowed to dry completely; fresh antiseptic  catheter connection when compared with opening the
                                                                                                    5
            ointment on sterile gauze is applied; and the catheter is  tubing system to attach a syringe directly. The patient’s
            rewrapped.                                          end of fluid administration tubing must be anchored to
              Removal of percutaneously inserted through-the-nee-  the catheter bandage with a piece of white tape to relieve
            dle catheters is also routinely considered after 4 days;  traction on the catheter connector (“T” piece or similar
            however, they may be safely left in place for much longer  device) and prevent separation. If the animal needs to
            periods if they were inserted using a long subcutaneous  be moved, avoid disconnecting the fluid line whenever
            tunnel and are carefully maintained. 48  If intravenous ther-  possible. If a needleless connector is not used, the fluid
            apy is to be continued, a new catheter is inserted before  line should be clamped at the “T” piece and the fluid
            the old one is removed whenever possible. Intraosseous  bag and line carried with the patient.
            catheters are removed when they are no longer needed,  All intravenous tubing and containers are changed
            when fluid begins leaking into surrounding tissue or by  every 72 hours or sooner if contamination is suspected.
            48 hours, whichever comes first. Surgically inserted  Injection ports and needleless connection devices should
            catheters made of inert materials and with long subcuta-  be cleaned carefully with 70% isopropanol before needle
            neous tunnels may be left in place for days to months.  puncture. Injection port caps are replaced if they are
              Catheters in use for continuous fluid therapy probably  observed to leak or if they have been penetrated more
            do not need to be flushed periodically to prevent catheter  than approximately 20 times.
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