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378        FLUID THERAPY


            patient’s end of the administration tubing to the catheter  continuously drive fluid at a constant rate. Cassette-style
            bandage helps prevent disconnection at the catheter. Use  pumps require an in-line fluid path pump mechanism
            of locking Luer connections (as opposed to slip-Luer  (cassette) as an integral component of an intravenous
            connections) is the best way to reduce the likelihood of  fluid administration set that works only with a specific
            an accidental disconnection. Those junctions may also  model(s) of pump. When fluids need to be given at a very
            be bridged with waterproof white tape to further reduce  constant rate from moment to moment, peristaltic pumps
            that risk.                                           are generally better than cassette designs, which alternate
                                                                 between pulling fluid from the bag and pushing it to the
            FLUID ADMINISTRATION                                 patient. Peristaltic pumps are less accurate over time, and
            AND MONITORING                                       their accuracy also depends on using an approved intrave-
                                                                 nous tubing set and changing the tubing position within
            The many different types of available fluid administration  the pump at regular intervals. Metered cassette pumps are
            sets and connection devices offer considerable flexibility  volumetric and are used to deliver prescribed volumes of
            in intravenous fluid administration. Multiple port flow  fluid accurately over longer units of time (many minutes
            connectors allow simultaneous infusion of compatible  to hours). The rate-constant peristaltic type of fluid pump
            solutions through a single catheter. In-line volume con-  (or a screw mechanism syringe pump for small volumes) is
            trol sets (Buretrol, Baxter Healthcare) permit accurate  useful for infusions of fluid with drug additives that
            delivery of small volumes of fluids. A variety of different  require a constant flow rate (e.g., a consistent minute-
            tubing lengths, diameters, and connections allow many  to-minute dose of norepinephrine), whereas the volu-
            different configurations and combinations of fluids to  metric pumps are preferred for accurate administration
            be delivered to a single catheter. Fluid administration sets  of prescribed volumes of fluid over longer units of time
            are available from several manufacturers. The two basic  (e.g., hour-to-hour). Pumps marketed specifically for
            types are vented and nonvented; these are available in sev-  use in animals are available (e.g., Vet/IV, Heska, Fort
            eral lengths. All administration sets use an in-line drip  Collins, Colo.).
            chamber to estimate the rate of flow. Depending on     All pumps deliver fluid under pressure. This pressure
                                                                 can overcome resistance to flow from viscous solutions,
            the brand, the drip sizes are calibrated so that 1 mL ¼
            10, 15, 20, or 60 drops. Drops per minute are calculated  filters, and partially occluded veins. It also increases the
            from the formula:                                    risk to the patient in the case of extravasation because
                                                                 fluid is pumped into the perivascular tissues under pres-
                                                                 sure. To prevent this, most modern pumps are equipped
            Drops per minute ¼ total infusion volume
                                                                 with pressure monitoring circuitry and some can be
                               drops=mL=Total infusion time ð minÞ
                                                                 adjusted to produce an occlusion alarm at preset values.
                                                                   Intravenous solution containers should be numbered
            For example, to administer 2000 mL over 24 hours using  consecutively and clearly labeled with the date, time,
            a basic solution set (10 drops ¼ 1mL):               and patient’s name. Any additives should be clearly
                                                                 identified as to type, quantity added, date and time
                 ð2000 mL   10 drops=mLÞ=1440 minutes            added, and by whom. Do not use an indelible marker
                   ¼ 14 drops= min                               to write directly on the bag because the solvents in the
                                                                 ink may leach through the plastic into the solution inside.
            The rate of flow is regulated by tightening or releasing the  When not using a volumetric pump that tracks cumula-
            intravenous tubing clamp while watching and counting  tive fluid administered, a calibrated timing label should
            the drip rate. Fluid administration rate may also be con-  be applied to the container and is used to monitor and
            trolled by in-line flow regulators (Stat 2 Pumpette,  verify the rate of flow over time.
            ConMed Corp., Utica, N.Y.) or more accurately by elec-  All patients receiving intravenous fluid therapy should
            tronic fluid pumps or rate controllers. In-line flow  be weighed at least daily. Abnormal fluid losses through
            regulators are calibrated tubing clamps. Accurate use of  the urinary tract, nasogastric suction, or cavity drainage
            these devices depends on unimpeded flow through short  should be measured and replaced with equal volumes
            catheters 20 gauge or larger and on maintaining a mini-  of appropriate intravenous replacement fluids at frequent
            mum height of about 75 cm (30 inches) between the drip  intervals. Fluid losses in animals with vomiting or diar-
            chamber and the level of the heart.                  rhea may be monitored by knowing the average dry
               Fluid pumps are available from many manufacturers.  weight of cage paper used in the clinic and subtracting
            All are either peristaltic or metered cassette in design  this from the weight of soiled cage papers. The difference
            (Figure 15-10). Peristaltic pumps typically use standard  (in grams) is converted to milliliters of water and replaced
            intravenous administration sets, although some devices  with appropriate intravenous replacement fluid. Monitor-
            are restricted to certain brands of tubing. This pump  ing of the PCV and total plasma solids is an inaccurate
            design uses a continuous peristalsis mechanism to    (PCV) and insensitive (total plasma solids) indicator of
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