Page 176 - The Toxicology of Fishes

156 The Toxicology of Fishes

Product (ROH)

RH–substrate
ROH Fe 3+ Fe 3+

RH FeO 3+ 3+
H 2 O Fe (RH)
e –
H +
2+
2+
RH Fe OOH Fe (RH)
O 2
2+
RH Fe –O 2
e –

FIGURE 4.1 CYP catalytic cycle.

Hydroxylation of aliphatic carbons
OH
COOH COOH
Lauric acid ω–1 hydroxylation

Hydroxylation of aromatic carbons
OH OH
HO

OH HO
17β-Estradiol

Epoxidation
O O O O
O
O O
O O
O O OCH3
OCH3
Aflatoxin B1

Heteroatom dealkylation
HO O O
C 2 H 5 O O O
N
N Ethoxyresorufin O-deethylase
Resorufin
Ethoxyresorufin EROD
FIGURE 4.2A Examples of reactions catalyzed by cytochrome P450.