Page 179 - The Toxicology of Fishes

Biotransformation in Fishes 159

TABLE 4.2 (cont.)
CYP Gene Families, Inducers, Inhibitors, and Substrates
P450
Gene Substrates Inducers Inhibitors

CYP2P3 Arachidonic acid TPA/starvation (decrease mRNA) ?
Benzphetamine
Arachidonic acid TPA/starvation (decrease mRNA) ?
Benzphetamine
Alkoxyresorufins
CYP2X1 Benzphetamine ? ?
Aminopyrene
CYP3A27 Testosterone (6β,16β−ΟΗ) Ketoconazole α-Naphthoflavone
Progesterone Estrogens (decrease) Parathion
Estradiol Ketoconazole
BaP Miconazole
Clotrimazole
Nifedipine SKF525A
Benzphetamine Cimetidine
Ethoxycoumarin Elipticine
Piperonyl butoxide
Isosafrole
Gestoden
17α-Ethinylestradiol
1-Aminobenzotriazole
5,8,11,14-Eicosatetraynoic acid
CYP3A38 Testosterone (6β,16β−ΟΗ) Estrogens (decrease) Nonylphenol (>100 nM)
Benzyloxyresorufin
7-Benzyloxy-4-[trifluoromethyl]-
coumarin
CYP3A40 Testosterone (6β) — —
Benzyloxyresorufin
7-Benzyloxy-4-[trifluoromethyl]-
coumarin
CYP3A45 Testosterone (6β) — —

Benzo(a)pyrene
12 1
11 2
10 EH HO
9 3 CYP1A UGT O
H H O
4 O
8 HO HO OH
7 6 5 O H OH H
GST OH HO H
CYP1, CYP2,
or CYP3 CYP1A
SG
O
OH GST HO
GS
OH HO HO
SULT UGT OH reaction OH
with DNA
DNA
HO
O Oglucuronide
O SOH HO
O OH
FIGURE 4.3 Biotransformation pathway of benzo(a)pyrene (BaP).