Page 275 - The Toxicology of Fishes
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Receptor-Mediated Mechanisms of Toxicity 255
Chapman et al. (2004) Gurvich et al. (2005) van der Ven et al. (2005) Handley-Goldstone et al. (2005) Carney et al. (2006) Hahn et al. (2007) Andreasen et al. (2002) Vuori et al. (2006) Volz et al. (2005, 2006) Hoffmann et al. (2006)
Complement component C3 (–), glutathione peroxidases (–), GSTA3 (–), peroxiredoxin (–) Similar to effects of HDAC inhibitor Sex difference; more genes downregulated CYP1 (+), cardiac troponin, myosin (+), mitochondrial energy transfer genes (+) Phase I/II metabolism (+), cell-cycle regulators (+), DNA replication (–) Glutathione function and metabolism (+) Phase I/II metabolism (+), extracellular matrix (+)(–), Frizzled 7a (+), sox9b (–), collagen m
SSH, macroarray Oligo microarray (Affymetrix ® ) Brain-specific cDNA microarray (682) Heart-specific cDNA microarray (5184) Oligo microarray (Affymetrix ® ) Long oligo array (Agilent) (21,495) Oligo microarray (Affymetrix ® ) (14,900) Salmonid cDNA array (1380) SSH, cDNA macroarrays (42,175) Oligo microarray (Affymetrix ® ) (14,900)
Chromium (VI) Valproic acid Chlorpromazine TCDD TCDD tert-Butylhydroquinone (tBHQ) Regenerating vs. normal fin ± TCDD M74 vs. healthy TCDD 17α-Ethynylestradiol (+) = upregulated; (–) = downregulated
Winter flounder (Pseudopleuronectes americanus) adults Zebrafish (Danio rerio) embryos (25 hpf) Zebrafish adults Zebrafish larvae (3 dpf) Zebrafish larvae (3 dpf) Zebrafish larvae (4 dpf) Zebrafish adults Atlantic salmon (Salmo salar) fry Medaka (Oryzias latipes) adults Zebrafish adults Note:
