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or against expired lung volume during a respiratory   These devices are best utilized to confirm proper
            cycle (volume capnogram).                    endotracheal intubation. The device is placed at the
  VetBooks.ir  efficiency of ventilation. It is the most commonly   end of the endotracheal tube (ETT). If the color
              The time capnogram gives an indication of the
                                                         does  not  change, there  is a  high  chance  the  ETT
            used method because it is simple to use, evaluates
                                                         tioned. It is important to wait for six breaths before
            both parts of the respiratory cycle (inspiration and   tube is in the esophagus and it needs to be reposi-
            expiration), and is an excellent tool for patient   deciding if the ETT is properly placed.
            monitoring at bedside. The volume capnogram has
            its own benefits too: it allows a breath-by-breath
            quantification of the volume of lung ventilated, as   Quantitative capnometry
            well as the measurement of alveolar dead space, and   There are multiple physical methods that can be
            physiological dead space. This means that the clini-  used to  quantitatively measure CO  : (i) infrared
                                                                                     2
            cian can assess the degree of ventilation/perfusion   spectroscopy;  (ii)  molecular  correlation  spectros-
            (V/Q) mismatch. Different physiological concepts   copy; (iii) Raman spectrography; (iv) photo acous-
            can  be  used  (i.e.  Bohr  or  Enghoff  approach)  to   tic spectrography; (v) mass spectrography; and (vi)
            quantify the global V/Q mismatches. This method   chemical colorimetric analysis spectrography.
            also allows separation of shunt fraction (blood   The most commonly used principle is the meas-
            passing by unventilated alveoli) and true dead space   ure of infrared light; therefore, this method will be
            (air not available for gas exchange). The major limi-  described in more detail in this chapter. This prin-
            tations of volume capnograms include the require-  ciple uses the application of the Beer and Lambert
            ment to use a mechanical ventilator and other   Laws and infrared waves.  This means that the
            elaborate equipment and it only provides informa-  quantity  of  infrared  (IR)  waveforms  absorbed  is
            tion regarding the expiratory phase of the breathing   proportional to the concentration of the infrared-
            cycle (as the expired CO  is plotted against expired   absorbing substance. In other words, the quantity
                               2
            lung volume).                                of infrared waveforms absorbed by CO  molecules
                                                                                       2
              This chapter will only focus on time capnograms.  is proportional to the concentration of CO  present
                                                                                         2
              A time capnograph provides a graphic represen-  in the expired gas. The higher the CO  concentra-
                                                                                       2
            tation (waveform) denoting the relationship of the   tion the higher the quantity of IR absorbed. This
            ETCO  concentration to time. It also provides a   concept might seem difficult to follow, but it will be
                 2
            measured value of the maximum level of ETCO  at   described in more detail below.
                                                 2
            the end of each breath. Changes in size, shape, and   A capnograph using infrared spectroscopy con-
            distribution  of  the  waveforms  are  suggestive  of   tains three main components: (i) infrared source;
            underlying pathologic conditions while changes in   (ii) sample chamber; and (iii) infrared detector.
            the level of measured ETCO  reflect disease sever-
                                   2
            ity as well as response to treatment.
              Capnometry is further classified based on the   The infrared source
            technique used to measure CO  concentration:  As the name implies, the infrared source emits
                                    2
             ● ● Qualitative capnometry: provides a color-coded   infrared waves. The infrared waves are absorbed by
                                                         different gases present in the anesthesia circuit.
               (colorimetric) capnogram representing the pres-  Each gas absorbs infrared waves of different wave-
               ence of CO  in the patient’s breath.      lengths. For example, CO  absorbs infrared wave-
                       2
                                                                             2
             ● ● Quantitative capnometry: provides a numeric   lengths of 4.25 micrometers, nitrous oxide absorbs
               value for the measured CO  concentration. It   infrared wavelengths of 4.5 micrometers, while
                                     2
               can also provide a graphic form which is called   oxygen does not absorb infrared light.
               ‘quantitative capnography.’
                                                          Why is this important? Because knowing the
                                                         wavelength absorption of a certain gas (in our case
                                                         the CO ), a device can be designed with an infrared
            Qualitative capnometry                            2
                                                         source that will only emit that specific wavelength
            Qualitative (colorimetric) capnographs are hand-  and only measure the concentration of that gas. If the
            held devices which contain a pH-sensitive impreg-  source were to emit a wide spectrum of wavelengths,
            nated paper. If the exhaled gas contains CO  the   then it might measure the concentration of other
                                                2,
            color of the paper changes from purple to yellow.   gases that are not of importance and the final reading
             112                                                                         L.A.M. Ilie
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