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Aflatoxins Chapter | 69 993
VetBooks.ir naturally occurring carcinogen. AFs target the liver, the Chaytor, A.C., See, M.T., Hansen, J.A., et al., 2011. Effects of chronic
exposure of diets with reduced concentrations of aflatoxin and deox-
immune system, reproduction, and have teratogenic and
ynivalenol on growth and immune status of pigs. J. Anim. Sci. 89,
epigenetic effects. The differences between species in the
toxication of AFs, especially AFB 1 , likely explain species 124 135.
Clark, J.D., Mahaffey, E.A., Hatch, R.C., et al., 1980. Experimentally induced
differences in toxicity. The reaction of AFB 1 epoxide
chronic aflatoxicosis in rabbits. Am. J. Vet. Res. 41, 1841 1845.
with DNA, RNA, and proteins are important mechanisms
Cook, W.O., Richard, J.L., Osweiler, G.D., et al., 1986. Clinical and
of intoxication. Agronomic practices, pest control, and
pathologic changes in acute bovine aflatoxicosis: rumen motility and
ensuring that stored commodities cannot support growth
tissue and fluid concentrations of aflatoxins B 1 and M 1 . Am. J. Vet.
of fungi are the best control for prevention of AF contam- Res. 47, 1187 1825.
ination of foods and feeds. For future direction, there is a Coppock, R.W., Dziwenka, M., 2016. Green tea extract. In: Gupta, R.C.
need to investigate the excretion of AFB 1 -adducts by (Ed.), Nutraceuticals. Efficacy, Safety and Toxicity. Academic
domestic and companion animals for use as a diagnostic Press/Elsevier, Amsterdam, pp. 633 652.
test for exposure. The interactions of mycotoxins are Coppock, R.W., Jacobsen, B.J., 2009. Mycotoxins in animal and human
important considerations in terms of predicting safe expo- patients. Toxicol. Ind. Health. 25, 637 655.
sure of humans and animals to mycotoxins. Coppock, R.W., Reynolds, R.D., Buck, W.B., et al., 1989. Acute aflatox-
icosis in feeder pigs, resulting from improper storage of corn. J. Am.
Vet. Med. Assoc. 195, 1380 1381.
REFERENCES Coppock, R.W., Christian, R.G., Jacobsen, B.J., 2012. Aflatoxins.
In: Gupta, R.C. (Ed.), Veterinary Toxicology Basic and Clinical
Abdelsalam, E.B., el-Tayeb, A.E., Nor Eldin, A.A., et al., 1989. Principles, second ed. Elsevier, Toronto.
Aflatoxicosis in fattening sheep. Vet. Rec. 124, 487 488. Cullen, J.M., Newberne, P.M., 1994. Acute hepatotoxicity of aflatoxins.
Allcroft, R., Lewis, G., 1963. Groundnut toxicity in cattle: experimental In: Eaton, D.L., Groopman, J.D. (Eds.), The Toxicology of
poisoning of calves and a report on clinical effects in older cattle. Aflatoxins. Human Health, Veterinary, and Agricultural
Vet. Rec. 75, 487 493. Significance. Academic Press, Toronto.
Angsubhakorn, S., Poomvises, P., Romruen, K., et al., 1981. Dilkin, P., Zorzete, P., Simas, M.M., et al., 2003. Toxicological effects
Aflatoxicosis in horses. J. Am. Vet. Med. Assoc. 178, 274 278. of chronic low doses of aflatoxin B 1 and fumonisin B 1 -containing
Bastianello, S.S., Nesbit, J.W., Williams, M.C., et al., 1987. Pathological Fusarium moniliforme culture material in weaned piglets. Food
findings in natural outbreak of aflatoxicosis in dogs. Onderstepoort Chem. Toxicol. 41, 1345 1353.
J. Vet. Res. 54, 635 640. Dorner, J.W., 2008. Management and prevention of mycotoxins in pea-
Battacone, G.A., Nudda, M., Palomba, M., et al., 2005. Transfer of afla- nuts. Food Addit. Contam. 25, 203 208.
toxin B 1 from feed to milk and from milk to curd and whey in dairy Eaton, D.L., Gallagher, E.P., 1994. Mechanisms of aflatoxin carcinogen-
sheep fed artificially contaminated concentrates. J. Dairy Sci. 88, esis. Annu. Rev. Pharmacol. Toxicol. 34, 135 172.
3063 3069. Ehrlich, K.C., 2014. Non-aflatoxigenic Aspergillus flavus to prevent afla-
Battacone, G.A., Nudda, M., Palomba, M., et al., 2009. The transfer of toxin contamination in crops: advantages and limitations. Front.
aflatoxin M 1 in milk of ewes fed diet naturally contaminated by afla- Microbiol. 5, 50.
toxins and effect of inclusion of dried yeast culture in the diet. J. Fernandez, A., Hernandez, M., Verde, M.T., et al., 2000. Effect of afla-
Dairy Sci. 92, 4997 5004. toxin on performance, hematology, and clinical immunology in
Becker-Algeri, T.A., Castagnaro, D., de Bortoli, K., et al., 2016. lambs. Can. J. Vet. Res. 64, 53 58.
Mycotoxins in bovine milk and dairy products: a review. J. Food Frehse, M.S., Martins, M.I., Ono, E.Y., et al., 2015. Aflatoxins ingestion
Sci. 81, R544 552. and canine mammary tumors: there is an association? Food Chem.
Bingham, A.K., Huebner, H.J., Phillips, T.D., et al., 2004. Identification Toxicol. 84, 74 78.
and reduction of urinary aflatoxin metabolites in dogs. Food Chem. Gemechu-Hatewu, M., Platt, K.L., Oesch, F., et al., 1996. Distribution and
Toxicol. 42, 1851 1858. induction of aflatoxin B 1 -9a-hydroxylase activity in rat liver paren-
Bortell, R., Asquith, R.L., Edds, G.T., et al., 1983. Acute experimentally chymal and non-parenchymal cells. Arch. Toxicol. 70, 553 558.
induced aflatoxicosis in the weanling pony. Am. J. Vet. Res. 44, Hall, R.F., Harrison, L.R., Colvin, B.M., 1989. Aflatoxicosis in cattle
2110 2114. pastured in a field of sweet corn. J. Am. Vet. Med. Assoc. 194, 938.
Bruchim, Y., Segev, G., Sela, U., et al., 2012. Accidental fatal aflatoxi- Harvey, R.B., Edrington, T.S., Kubena, L.F., et al., 1995. Influence of
cosis due to contaminated commercial diet in 50 dogs. Res. Vet. Sci. aflatoxin and fumonisin B 1 -containing culture material on growing
93, 279 287. barrows. Am. J. Vet. Res. 56, 1668 1672.
Butler, W.H., 1964. Acute toxicity of aflatoxin B 1 in rats. Br. J. Cancer. Helferich, W.G., Garrett, W.N., Hsieh, D.P., et al., 1986. Feedlot perfor-
18, 756 758. mance and tissue residues of cattle consuming diets containing afla-
Carlton, W.W., Szczech, G.M., 1978. Mycotoxicosis in laboratory ani- toxins. J. Anim. Sci. 62, 691 696.
mals. In: Wyllie, T.W., Morehouse, L.G. (Eds.), Mycotoxic Fungi. Henry, S.H., Bosch, F.X., Bowers, J.C., et al., 2002. Aflatoxin, hepatitis
Mycotoxins, Mycotoxicoses. An Encyclopedic Handbook, vol. 2. and worldwide liver cancer risks. Adv. Exp. Med. Biol. 504, 229 233.
Marcel Dekker, New York, New York. Ibeh, I.N., Uraih, N., Ogonar, J.I., et al., 1994. Dietary exposure to afla-
Chaffee, V.W., Edds, G.T., Himes, J.A., et al., 1969. Aflatoxicosis in toxin in human male infertility in Benin City, Nigeria. Int. J. Fertil.
dogs. Am. J. Vet. Res. 30, 1737 1748. Menopausal. Stud. 39, 208 214.