Page 288 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

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VetBooks.ir attempted to further design novel hypotheses to test the Brown, S.A., 2001. Pharmakokinetics: disposition and fate of drugs in
the body. In: Adams, R. (Ed.), Veterinary Pharmacology and
molecular players involved in liver damage (Craig et al.,
Therapeutics, 8th edn Iowa State University Press, Ames, IA,
2006; Blomme et al., 2009; Kienhuis et al., 2011).
Toxicogenomics will enable the detection of specific pp. 15 56.
Burrows, G.E., Tyrl, R.J., 2001. Toxic Plants of North America. Iowa
biomarkers used to predict adverse drug effects at low-
State University Press, Ames, IA, pp. 1196 1200.
level exposure (Kienhuis et al., 2011). Several signature
Can, C., Nigogosyan, G., 1963. Acquired toxic porphyria cutanea tarda
biomarkers have been elucidated that may eventually be
due to hexachlorobenzene. Report of 348 cases caused by this fungi-
useful in the diagnosis of hepatotoxicosis: serum
cide. JAMA. 183, 88 91.
proteomic analysis revealed increased concentrations of Center, S.A., Elston, T.H., Rowland, P.H., et al., 1996. Fulminant hepatic
vitamin D-binding protein, malate dehydrogenase, and failure associated with oral administration of diazepam in 11 cats. J.
purine nucleoside phosphorylase in several models of Am. Vet. Med. Assoc. 209, 618 625.
chemically induced hepatopathies. These enzymes were Chapman, S.E., Hostutler, R.A., 2013. A laboratory diagnostic approach
elevated in the serum before microscopic changes or to hepatobiliary disease in small animals. Vet. Clin. North Amer.
conventional serum markers such as transaminase or Small Anim. Pract. 43, 1209 1225.
alkaline phosphates elevations (Amacher et al., 2005). Court, M.H., 2001. Acetaminophen UDP-glucuronosyltransferase in fer-
rets: species and gender differences, and sequence analysis of ferret
Once validated for use in humans and domestic animals,
UGT1A6. J. Vet. Pharmacol. Ther. 24, 415 422.
these proteins are potentially predictive of hepatotoxic-
Court, M.H., Greenblatt, D.J., 1997. Molecular basis for deficient acet-
ity. The use of biomarkers will assist in identifying drugs
aminophen glucuronidation in cats. An interspecies comparison of
that can cause serious adverse reactions, such as idiosyn-
enzyme kinetics in liver microsomes. Biochem. Pharmacol. 53,
cratic liver injury, that could be missed in conventional 1041 1047.
preclinical or clinical drug trials. Further, research Craig, A., Sidaway, J., Holmes, E., et al., 2006. Systems toxicology:
involving transgenic and knockout models provides integrated genomic, proteomic and metabonomic analysis of metha-
insight into the mechanistic and molecular basis of liver pyrilene induced hepatotoxicity in the rat. J. Proteome Res. 5,
injury. 1586 1601.
Genetic predispositions to idiosyncratic drug reactions Crawford, J.M., 1999. The liver and the biliary tract. In: Cotran, R.S.,
have been elucidated in humans, such as sensitivity to Kumar, V., Collins, T. (Eds.), Robbins: Pathologica Basis of
Disease, sixth ed. Saunders, Philadelphia, pp. 845 901.
diclofenac and other xenobiotics in patients with a muta-
Cullen, J.M., 2005. Mechanistic classification of liver injury. Toxicol.
tion in the gene for multidrug resistance-associated pro-
Pathol. 33, 6 8.
tein 2. Mutations in the genes for superoxide dismutase
Dahm, L.J., Jones, D.P., 1996. Mechanisms of chemically induced liver
and GSH transferase also account for increased suscepti-
disease. In: Zakim, D., Boyer, T.D. (Eds.), Hepatology, A Textbook of
bility to the toxic effects of certain drugs (Stirnimann Liver Disease. W.B. Saunders Company, Philidelphia, pp. 875 890.
et al., 2010). Animal models for idiosyncratic drug reac- Delgado-Coello, B., Trejo, R., Mas-Oliva, J., 2006. Is there a specific
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tions remain elusive, but form another area requiring role for the plasma membrane Ca -ATPase in the hepatocyte? Mol.
investigation. Cell Biochem. 285, 1 15.
Dereszynski, D.M., Center, S.A., Randolph, J.F., et al., 2008. Clinical
and clinicopathologic features of dogs that consumed foodborne
hepatotoxic aflatoxins: 72 cases (2005 2006). J. Am. Vet. Med.
REFERENCES Assoc. 232, 1329 1337.
Di Luzio, N.R., 1966. A mechanism of the acute ethanol-induced fatty
Amacher, D.E., Adler, R., Herath, A., Townsend, R.R., 2005. Use of
liver and the modification of liver injury by antioxidants. Am. J.
proteomic methods to identify serum biomarkers associated with rat
Pharm. Sci. Support Public Health. 15, 50 63.
liver toxicity or hypertrophy. Clin. Chem. 51, 1796 1803.
Diehl, A.M., 2002. Nonalcoholic steatosis and steatohepatitis. IV.
Apte, U.M., Banerjee, A., McRee, R., et al., 2005. Role of osteopontin
Nonalcoholic fatty liver disease abnormalities in macrophage function
in hepatic neutrophil infiltration during alcoholic steatohepatitis.
and cytokines. Am. J. Physiol. Gastrointest Liver Physiol. 282, 1 5.
Toxicol. Appl. Pharmacol. 207, 25 38.
Dirksen, K., Fieten, H., 2017. Canine copper-associated hepatitis. Vet.
Bardag-Gorce, F., Yuan, Q.X., et al., 2000. The effect of ethanol-
Clin. North Amer. Small Anim. Pract. 47 (3), 631 644.
induced cytochrome p4502E1 on the inhibition of proteasome activ-
Farrell, G.C., Duddy, S.K., Kass, G.E., et al., 1990. Release of Ca 21
ity by alcohol. Biochem. Biophys. Res. Commun. 279, 23 29.
from the endoplasmic reticulum is not the mechanism for bile acid-
Bastianello, S.S., Nesbit, J.W., Williams, M.C., Lange, A.L., 1987.
induced cholestasis and hepatotoxicity in the intact rat liver. J. Clin.
Pathological findings in a natural outbreak of aflatoxicosis in dogs.
Invest. 85, 1255 1259.
Onderstepoort J. Vet. Res. 54, 635 640.
Fausto, N., Campbell, J.S., 2003. The role of hepatocytes and oval cells
Bautista, A.P., 2002. Neutrophilic infiltration in alcoholic hepatitis.
in liver regeneration and repopulation. Mech. Dev. 120, 117 130.
Alcohology. 27, 17 21.
French, S.W., 2003. Alcoholic liver disease. In: Zakim, D., Boyer, T.D.
Blomme, E.A., Yang, Y., Waring, J.F., 2009. Use of toxicogenomics to
(Eds.), Hepatology, A Textbook of Liver Disease. W.B. Saunders
understand mechanisms of drug-induced hepatotoxicity during drug
Company, Philidelphia, pp. 839 922.
discovery and development. Toxicol. Lett. 186, 22 31.