Page 65 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

32 SECTION | I General

VetBooks.ir Institute (1966 88) (now a part of the Lovelace Respiratory Albert, R.E., 1994. Carcinogen risk assessment in the U.S. Environmental
Protection Agency. Crit. Rev. Toxicol. 24, 70 85.
Research Institute) in Albuquerque, New Mexico; and the Chemical
Anastas, P.T., Warner, J.C., 1998. Green Chemistry: Theory and
Industry Institute of Toxicology (1988 99) (in later years the
Practice. Oxford University Press, Oxford.
Hamner Institutes Health Sciences) in Research Triangle Park,
North Carolina. Moreover, my insights and their role in informing Anonymous, 2008. Obituary for Charles C. Capen. Toxicol. Pathol. 36,
important societal decisions on human and animal health and envi- 373 374.
ronmental impacts have been sharpened by my experience serving ATSDR, Agency for Toxic Substances and Disease Registry, 2006.
as an advisor on toxicology and human health risk issues to public Toxicological Profiles and Minimal Risk Levels for Hazardous
agencies and private clients and the opportunities I have had for Substances ,http://www.atsdr.cdc.gov/mrls.html..
working with many outstanding toxicologists and other scientists. Attfield, M.D., Schleiff, P.L., lubin, J.H., et al., 2012. The diesel exhaust
The excellent assistance of my long-time associate, Mildred in miners study: a cohort mortality study with emphasis on lung can-
Morgan, in preparing this chapter and the useful review comments cer. J. Natl. Cancer Inst. 104, 1 15.
of Drs. Ramesh C. Gupta, Fred W. Oehme, and Mike Murphy on AVMA (American Veterinary Medical Association), One Health
drafts of earlier chapters are gratefully acknowledged. Initiative Task Force: Final Report, July 15, 2008.
Ayres, J.G., Harrison, R.M., Maynard, R., et al., 2010a. Textbook of
Environmental Medicine, first ed. Hodder Arnold, London.
POSTSCRIPT Ayres, J.G., Harrison, R.M., Maynard, R., McClellan, R.O., et al., 2010b.
Chapter 1, Environmental Medicine. In: Ayres, J.G., Harrison, R.M.,
Over the decades, I have come to appreciate that every Nichols, G.L., Maynard, R. (Eds.), Textbook of Environmental
sector of society (academic, government, industry, and Medicine, first ed. Hodder Arnold (Publisher), London, pp. 3 21.
private consulting firms) includes many highly qualified Ball, D.J., Blanchard, J., Jacobson-Kram, D., McClellan, R.O., et al.,
individuals. What one learns from experience is that what is 2007. Development of safety qualification thresholds and their use
important is the personal knowledge and integrity that each in drug product evaluation. Toxicol. Sci. 97 (2), 226 236.
of these individuals brings to the forum, not who they are Ball, D.J., Norwood, D.L., Stults, C.L.M., Nagao, L.M. (Eds.), 2012.
employed by at the time. It is especially gratifying when Leachables and Extractables Handbook: Safety Evaluation,
Qualification and Best Practices Applied to Inhalation Drug
many of these professional associates over time become
Products. John Wiley and Sons, Hoboken, NJ.
friends. One of those special friends was John Doull
Beyer, L.A., Beck, B.D., Lewandowski, T.A., 2011. Historical perspective
(1922 2017) who passed away on March 24, 2017 as I was
on the use of animal bioassays to predict carcinogenicity: evolution in
finishing revision of this chapter. My primary mentor, Leo design and recognition of utility. Crit. Rev. Toxicol. 41, 321 338.
Bustad, arranged for me to visit John Doull and his collea- Brusick, D., Aardema, M., Kier, L., et al., 2016. Genotoxicity expert
gues at the University of Chicago in the fall of 1960. Out of panel review: weight of evidence evaluation of the genotoxicity of
that initial meeting developed a friendship that would extend glyphosate, glyphosate-based formulations, and aminomethylpho-
for 57 years. I knew I could always call on John for advice sphonic acid. Crit. Rev. Toxicol. 46 (Suppl. 1), 56 74.
and counsel. On many occasions in the past I would ask Burrows, G.E., Tyrl, R.S., 2006. Handbook of Toxic Plants of North
John to review drafts of a chapter such as this one to tell if America. Blackwell Publishing, Ames, IA.
Bustad, L.K., McClellan, R.O., Garner, R.J., 1965. The significance of
my writing made sense or if I had missed some important
radionuclide contamination in ruminants. Physiology of Digestion in
concepts. That was not to be the case with this chapter. I am
the Ruminant. Butterworth Inc, Washington, DC, pp. 131 146.
pleased that I was asked to author “A Tribute to John
Butterworth, B.E., Conolly, R.B., Morgan, K.T., 1995. A strategy for
Doull, BS, PhD, MD: Scientist, Physician, Educator,
establishing mode of action of chemical carcinogens as a guide for
Advisor and Above All, a Gentleman and Friend to Many approaches to risk assessments. Cancer Lett. 93, 129 146.
(McClellan, 2017).” John recognized the unique education CAA, 1970. The Clean Air Act Amendments of 1970-P.L. 91-04
of veterinarians in comparative medicine and their potential (December 31, 1970), Plus Technical Amendments Made by P.L.
for contributing to veterinary toxicology, toxicology in gen- 92 157 (November 18, 1971).
eral and, more broadly, to medical science and the well Calabrese, E.J., Baldwin, L.A., 2003. The hormesis model is more
being of human kind. We will all miss this giant in the field frequent that the threshold model in toxicology. Toxicol. Sci. 61,
of toxicology and medical science. 246 250.
Calabrese, E.J., Blain, R., 2005. The occurrence of hormetic dose
responses in the toxicological literature, the hormesis database: an
REFERENCES overview. Toxicol. Appl. Pharmacol. 202, 289 301.
Calabrese, E.J., et al. (57 co-authors including R.O. McClellan), 2007.
ACGIH, American Conference of Governmental Industrial Hygienists, Biological stress response terminology: integrating the concepts
2011. Threshold Limit Values and Biological Exposure Indices for of adaptive response and preconditioning stress within a hormetic
Chemical Substances and Physical Agents. Cincinnati, OH. dose-response framework. Toxicol. Appl. Pharmacol. 222, 122 128.
Acquavella, J., Garabrant, D., Marsh, G., et al., 2016. Glyphosate epidemi- Carmichael, N., Bausen, M., Boobis, A.R., et al., 2011. Using mode
ology expert panel review: a weight of evidence systematic review of of action information to improve regulatory decision-making:
the relationship between glyphosate exposure and nonHodgkins’s lym- an ECETOX/ILSI/RF/HESI Workshop overview. Crit. Rev. Toxcol.
phoma or multiple myeloma. Crit. Rev. Toxicol. 46 (S1), 28 43. 41, 175 186.