Page 1247 - Small Animal Internal Medicine, 6th Edition

CHAPTER 71 Diagnostic Testing for Immune-Mediated Disease 1219

TABLE 71.1
VetBooks.ir Clinical Indications for Use of Diagnostic Tests in Suspected Immune-Mediated Disease—cont’d

POTENTIAL IMMUNE-
MEDIATED CONDITIONS
CLINICAL SYNDROME TO CONSIDER TESTS INDICATED TO CONFIRM LIMITATIONS
Proteinuria Glomerulonephritis Urinalysis; protein/creatinine Need to rule out inflammation
ratio; renal biopsy for arising from the lower
histopathology, urinary tract before
immunofluorescence, electron interpreting protein/
microscopy creatinine ratio
Two of the previous clinical SLE ANA, LE preparation LE has very low sensitivity for
syndromes together or in diagnosis of SLE; ANA titer
combination with is more sensitive, but some
dysfunction of other dogs with SLE may have a
organ system negative ANA

ANA, Antinuclear antibody; CBC, complete blood count; IMHA, immune-mediated hemolytic anemia; LE, lupus erythematosus; SLE, systemic
lupus erythematosus.

Suggested Readings Smee NM, et al. Measurement of serum antinuclear antibody titer
in dogs with and without systemic lupus erythematosus: 120
Dircks BH, et al. Underlying diseases and clinicopathologic vari-
ables of thrombocytopenic dogs with and without platelet-bound cases (1997-2005). J Am Vet Med Assoc. 2007;230:1180.
antibodies detected by use of a flow cytometric assay: 83 cases Smith BE, et al. Antinuclear antibodies can be detected in dog sera
(2004-2006). J Am Vet Med Assoc. 2009;235:960. reactive to Bartonella vinsonii subsp., berkhoffii, Ehrlichia canis,
Eckersall PD, et al. Acute phase proteins: biomarkers of infection or Leishmania infantum antigens. J Vet Intern Med. 2004;18:47.
and inflammation in veterinary medicine. Vet J. 2010;185(1): Wardrop KJ. The Coombs’ test in veterinary medicine: past, present,
23–27. and future. Vet Clin Pathol. 2005;34:325.
Fournel C, et al. Canine systemic lupus erythematosus I: a study of Wardrop KJ. Coombs’ testing and its diagnostic significance in dogs
75 cases. Lupus. 1992;1:133. and cats. Vet Clin North Am Small Anim Pract. 2012;42:42.
Lewis DC, et al. Canine idiopathic thrombocytopenia. J Vet Intern
Med. 1996;10:207.