Page 1324 - Small Animal Internal Medicine, 6th Edition

1296 PART XII Oncology

TABLE 79.2
VetBooks.ir Clinical Signs and Physical Examination Findings in
Dogs and Cats With Extranodal Lymphomas
ORGAN CLINICAL PHYSICAL
INVOLVED PRESENTATION FINDING(S)
CNS Solitary or multifocal Any neurologic
CNS signs finding
Eye Blindness, infiltrates, Infiltrates, uveitis,
photophobia RD, glaucoma A
Kidney PU-PD, azotemia, Renomegaly, renal
erythrocytosis* masses
Lung Coughing, dyspnea None, radiographic
changes
Skin Any primary or Any primary or
secondary lesion secondary lesion

CNS, Central nervous system; PU-PD, polyuria/polydipsia; RD,
retinal detachment.
*Only in dogs.

B

FIG 79.4
Diffuse distal limb swelling, erythema, and ulceration in a
cat with epidermotropic cutaneous T-cell lymphoma, before
(A) and after chemotherapy (B).

lymphoma reported in the literature and seen by the authors
have been negative for FeLV viremia.
Ocular lymphoma occurs in both dogs and cats. In dogs,
it is commonly associated with the multicentric form,
whereas both primary ocular involvement and ocular
FIG 79.2 involvement associated with the multicentric form are
Diffuse desquamative dermatopathy in a 13-year-old female common in cats. A variety of signs and lesions may be
spayed dog with mycosis fungoides (a specific type of
epidermotropic cutaneous T-cell lymphoma). Clinical signs present in these patients, including photophobia, blepharo-
and lesions were present for almost 2 years. spasm, epiphora, hyphema, hypopyon, ocular masses, third
eyelid infiltration, anterior uveitis, chorioretinal involve-
ment, and retinal detachment.
Nasopharyngeal lymphoma is relatively common in cats
but is extremely rare in dogs. Clinical signs are similar to
those seen in cats with any upper respiratory tract disorder
and include sneezing, unilateral or bilateral nasal discharge
(ranging from mucopurulent to frankly hemorrhagic), ster-
torous breathing, exophthalmos, and facial deformity (Fig.
79.5); this is one of the most common forms of extranodal
lymphoma seen in cats at the authors’ clinics.
Renal lymphoma is relatively common in cats but uncom-
mon in dogs. Cats with this anatomic form are first evaluated
because of vague clinical signs, usually secondary to azote-
mia. On physical examination, the cat is often emaciated,
FIG 79.3 typically has pale mucous membranes from anemia, and has
Typical doughnut-shaped lesion in a Rottweiler with large, irregular, and firm kidneys; both kidneys are com-
cutaneous T-cell lymphoma. monly affected. There is a purported association between