Page 1349 - Small Animal Internal Medicine, 6th Edition
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CHAPTER 80   Leukemias   1321


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                                                                  kaemia  in  the  cat:  18  cases  (2000-2010).  Vet Comp Oncol.
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                                                                  labeling for CD18 and CD45. Vet Clin Pathol. 2006;35:47.
                                                                 Comazzi S, et al. Immunophenotype predicts survival time in dogs
               A                                                  with chronic lymphocytic leukemia. J Vet Intern Med. 2011;25:100.
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                                                                  transformation into high-grade lymphoma: a description of
                                                                  Richter’s syndrome in eight dogs.  Vet Comp Oncol. 2017;15:
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                                                                 Couto CG. Clinicopathologic aspects of acute leukemias in the dog.
                                                                  J Am Vet Med Assoc. 1985;186:681.
                                                                 Davis LL, Hume KR, Stokol T. A retrospective review of acute
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                                                                  cytochemical staining results (2007-2015).  Vet Comp Oncol.
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                                                                  pathological characteristics of spontaneous leukemia in 10 cats.
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                                                                 Grindem  CB,  et al.  Morphological  classification  and clinical  and
                                                                  pathological characteristics of spontaneous leukemia in 17 dogs.
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                                                                 Jain NC, et al. Proposed criteria for classification of acute myeloid
                                                                  leukemia in dogs and cats. Vet Clin Pathol. 1991;20:63.
               B                                                 Novacco M, et al. Prognostic factors in canine acute leukaemias: a
                                                                  retrospective study. Vet Comp Oncol. 2015a;14:409.
                                                                 Novacco M, et al. Analytic errors in Sysmex-generated hematology
            FIG 80.8                                              results in blood from a dog with chronic lymphocytic leukemia.
            Peripheral blood smears showing lymphocyte morphology in
            cats with chronic lymphocytic leukemia. Note the small   Vet Clin Pathol. 2015b;44:337.
            lymphocyte size, clumped chromatin, and cleaved nuclei.   Stokol T, et al. Alkaline phosphatase is a useful cytochemical
            Wright-Giemsa stain; ×1000 (A). Blood smear showing   marker for the diagnosis of acute myelomonocytic and mono-
            increased number of lymphocytes per field. Wright-Giemsa   cytic leukemia in the dog. Vet Clin Pathol. 2014;44:79.
            stain; ×500 (B).                                     Tasca S, et al. Hematologic abnormalities and flow cytometric
                                                                  immunophenotyping results in dogs with hematopoietic neopla-
                                                                  sia: 210 cases (2002-2006). Vet Clin Pathol. 2009;38(2).
                                                                 Weiss DJ. A retrospective study of the incidence and the classifica-
            18 cats with CLL revealed similar findings (Campbell et al.,   tion of bone marrow disorders in the dog at a veterinary teaching
            2012). Approximately 50% of the cats had clinical signs   hospital (1996-2004). J Vet Intern Med. 2006;20:955.
            related to their disease, with the most common clinical sign   Wilkerson MJ, et al. Lineage differentiation of canine lymphoma/
            being chronic weight loss. Various chemotherapy protocols   leukemias and aberrant expression of CD molecules. Vet Immunol
            were used, although chlorambucil and prednisolone were   Immunopathol. 2005;106:179.
            the most common; there was a response rate of 88%, with   Williams MJ, et al. Canine lymphoproliferative disease character-
            an MST of 14 months. As in dogs, CML is poorly character-  ized by lymphocytosis: immunophenotypic markers of progno-
                                                                  sis. J Vet Intern Med. 2008;22:506.
            ized in cats.

            Suggested Readings
            Avery AC, Avery PR. Determining the significance of persistent
              lymphocytosis. Vet Clin North Am Small Anim Pract. 2007;37:267.
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