Page 922 - Small Animal Internal Medicine, 6th Edition

894 PART VI Endocrine Disorders

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A

C B

FIG 50.21
(A) A 9-year-old male castrated domestic long-haired cat with a 2-year history of poorly
controlled diabetes mellitus, failure of hair to regrow after clipping 1 year before
presentation, and recent development of feline fragile skin syndrome. Diagnostic
evaluation revealed an adrenocortical tumor, increased serum progesterone concentration,
and suppression of the pituitary-adrenocortical axis on adrenocorticotropic hormone
stimulation and dexamethasone suppression testing. A progesterone-secreting
adrenocortical tumor was suspected. (B) Five weeks after initiation of treatment with
aminoglutethimide. Feline fragile skin syndrome was resolving, hair was growing, and
gynecomastia had developed. The serum progesterone concentration had decreased from
a pretreatment value of 4.7 ng/mL to less than 1 ng/mL. (C) Four months after
adrenalectomy. Insulin-requiring diabetes mellitus had resolved.

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