Page 1115 - Veterinary Immunology, 10th Edition

incompatible. When blood group A-O-compatible pigs are given
VetBooks.ir renal allografts, median survival is about 12 days for MHC–

unmatched grafts, 25 days for grafts compatible for MHC class I
alone, 32 days for grafts compatible for MHC class II alone, and 80

days for grafts compatible for both class I and class II (Fig. 34.2).
When dogs are given MHC–unmatched renal allografts, the grafts
survive for about 10 days. Completely matched allografts in dogs
survive for about 40 days. A more impressive result is obtained

with canine liver grafts, which survive for about 8 days in
unmatched animals and for 200 to 300 days in DLA–matched
recipients.

FIG. 34.2 Survival time of renal allografts between SLA-
incompatible minipigs clearly depends on the degree of MHC
compatibility between donor and host. (From Pescovitz MD, Thistlethwaite
JR Jr, Auchincloss H Jr, Ildstad ST, Sharp TG, Terrill R, Sachs DH. Effect of class II
antigen matching on renal allograft survival in miniature swine. J Exp Med
1160:1495-1508, 1984.)

The failure of MHC and blood group–compatible grafts to
survive indefinitely is a result of the cumulative effects of many
other minor antigenic differences. For example, skin grafts from
male donors placed on histocompatible females are usually

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