Page 1130 - Veterinary Immunology, 10th Edition

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FIG. 34.6 Induction of graft-versus-host disease in dogs that have
received a bone marrow allograft.

Graft-versus-Host Disease

If healthy lymphocytes are injected into the skin of an allogeneic
recipient, the lymphocytes attack the host cells and cause local
inflammation. Provided the recipient has a functioning immune

system, this graft-versus-host (GVH) reaction is not serious because
the recipient can destroy the foreign lymphocytes and thus
terminate the reaction. If, however, the recipient cannot reject the
grafted lymphocytes because it has been immunosuppressed or is

otherwise immunodeficient, the grafted cells may cause
uncontrolled destruction of the host's tissues and, eventually, death.
Thus GVH disease occurs in bone marrow allograft recipients who
have been effectively immunosuppressed by total-body irradiation

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