Page 1157 - Veterinary Immunology, 10th Edition

associated macrophages are usually of the M2 phenotype. This may
VetBooks.ir be due to IL-10 produced by Treg cells or from factors such as

monocyte chemotactic protein (MCP-1 or CCL2) secreted by the
cancer cells themselves. These M2 macrophages may enhance

tumor growth, suppress T and NK cell responses, promote
angiogenesis, and enhance cancer cell infiltration.

Antibody-Mediated Immunity

Antibodies to cancer cells are found in many tumor-bearing
animals; for instance, about 50% of dogs with lymphosarcomas
have antitumor antibodies. These antibodies may, together with
complement, lyse free cancer cells within the bloodstream.
Antibodies are not effective in destroying solid cancers.

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