Page 1221 - Veterinary Immunology, 10th Edition

recurrent uveitis. Three single nucleotide polymorphisms (SNPs)
VetBooks.ir are significantly correlated with the development of this disease.

One is on chromosome 1, and the other two are associated with the
equine MHC region (ELA). In German Warmbloods, the ELA-A9

haplotype is associated with increased susceptibility.

Uveodermatological Syndrome

Uveodermatological syndrome is a sporadic disease of dogs. A

similar disease, Vogt-Koyanagi-Harada syndrome, occurs in
humans. Affected dogs develop uveitis and skin depigmentation
with whitening of the hair (poliosis) and skin (vitiligo). The eye
lesions develop first and most animals present with sudden
blindness or chronic uveitis. The early lesions vary from a severe

panuveitis to a bilateral anterior uveitis. Some dogs may have
detached retinas, and there may be progressive depigmentation of
the retina and iris. Depigmentation of the hair and skin gradually

follows the onset of eye lesions. Some cases may be generalized,
involving the eyelids, nasal planum, lips, scrotum, and foot pads
(Fig. 37.2). These depigmented areas may become ulcerated and
crusted.

FIG. 37.2 A case of uveodermatological syndrome. Note ocular
clouding, alopecia, and depigmentation of the nasal planum.
(Courtesy Drs. R. Kennis, J. Dziezc, and L. Wadsworth.)

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