Page 759 - Veterinary Immunology, 10th Edition

contrast, lymphocytes from calves that received colostrum
VetBooks.ir containing live cells showed enhanced responses to BVDV antigen

at 1 and 2 days after colostral ingestion. The lymphocytes of calves
that received whole colostrum showed enhanced mitogenic

responses to maternal and unrelated leukocytes after 24 hours.
They also responded to the nonspecific stimulant staphylococcal
enterotoxin B. In contrast, the lymphocytes of calves that received
acellular colostrum did not. Clearly, ingestion of maternal colostral

leukocytes immediately after birth stimulates the development of
the neonatal immune system.
+
Mononuclear cells in mare's colostrum are mainly CD4 and CD8 +
+
T cells. CD8 cells in colostrum are enriched when compared to
blood. When stimulated with phorbol myristate acetate (PMA) and
ionomycin they produce more IL-17, similar IFN-γ, and less IL-4
and IL-10 when compared to blood cells. Thus these cells are
polarized towards IFN-γ and IL-17 production. This phenotype is

generally considered to promote inflammation.

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