Page 775 - Veterinary Immunology, 10th Edition

antibody may interfere with active immunization against the same
VetBooks.ir antigen. This is a phenomenon similar to that seen in newborn

animals passively protected by maternal antibodies.
Monoclonal antibodies are another source of passive protection

for animals. These are, however, mainly made by mouse-mouse
hybridomas and thus are mouse immunoglobulins. They will
therefore be antigenic when given to other species. Nevertheless,
mouse monoclonal antibodies against the K99 pilus antigens of

Escherichia coli may be given orally to calves to protect them against
diarrhea caused by this organism. A mouse monoclonal antibody to
lymphoma cells has been used to treat dogs. Monoclonal
antibodies, especially when modified to match the recipient species,

are increasingly used to treat inflammatory diseases and cancer in
humans and animals (Chapters 35 and 38).
Because of the need for large volumes of immunoglobulin-rich
fluids when passively immunizing agricultural species,

conventional methodology as described above may be unable to
provide sufficient antibodies (or too expensive). Some alternatives
include spray-dried blood plasma from normal pig blood used as a
feed additive, which contains about 20% immunoglobulin, and

surplus milk whey from cheese production where the protein
fraction contains about 10% immunoglobulins.

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