Page 788 - Veterinary Immunology, 10th Edition

glycoprotein can induce virus-neutralizing antibody and so confer
VetBooks.ir protection against rabies. Infection with this rabies-vaccinia

recombinant results in the production of antibodies to the G-protein
and the development of immunity. This vaccine has been

successfully used as an oral bait vaccine administered to wild
carnivores. This form of the vaccine can be distributed by dropping
from aircraft. It has been used in Ontario to prevent the spread of
fox rabies, in New Jersey to prevent the spread of raccoon rabies,

and in Texas to block the spread of coyote rabies. For example,
since 1995, 17.5 million doses of vaccinia-vectored rabies vaccine
have been air-dropped over 255,500 square miles (661,745 sq km) of
Texas with great success (Box 24.1).

788