Page 832 - Veterinary Immunology, 10th Edition

metaphyses, flared diaphyses, and formation of new periosteal
VetBooks.ir bone. Hind and fore limbs are equally affected. It is possible that

the condition is triggered in genetically susceptible animals by the
vaccine. The disease responds well to corticosteroid therapy. In

many cases, these dogs show a preexisting immune dysfunction
with low concentrations of one or more immunoglobulin classes,
recurrent infections, and inflammatory disease (Chapter 39). It has
been suggested that Weimaraners are especially susceptible to this

condition and that they therefore receive only killed virus vaccines.
A mild transient polyarthritis has been reported in some dogs
following vaccination. The dogs show a sudden onset of lameness
with swollen and painful joints within 2 weeks of vaccination. The

dogs recover within 2 days. No specific breed or vaccine has been
associated with this problem. Vaccination against calicivirus has
been associated with polyarthritis and a postvaccination limping
syndrome in cats.

Injection Site–Associated Sarcomas

The development of tumors (sarcomas) at sites of vaccine injection
is discussed in detail in Chapter 35.

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