Page 909 - Veterinary Immunology, 10th Edition
P. 909
have been expressed that the widespread use of MLV vaccines may
VetBooks.ir serve to seed viruses into animal populations and that untoward
consequences may develop in the future. This is a threat not to be
taken lightly.
An alternative approach to overcoming the problems caused by
MLV involves the increasing use of inactivated and subunit
vaccines. Excellent inactivated vaccines are available against
diseases such as foot-and-mouth disease, equine herpesvirus-4
(rhinopneumonitis), pseudorabies, feline panleukopenia, feline
herpes (rhinotracheitis), and rabies. At their best, these vaccines
confer immunity comparable in strength and duration to that
induced by MLV vaccines, with the assurance that they are free of
residual virulence. Virus-like particles are synthetic structures that
resemble viruses in structure and morphology and express viral
antigens. In effect, they are viruses without a contained genome.
They hold great potential for generating superior vaccines and are
described in more detail in Chapter 24.
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