Page 904 - Veterinary Immunology, 10th Edition

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FIG. 27.10 The serum protein electrophoretic patterns seen in
normal and Aleutian disease-infected mink. The serum of the
infected animal shows a polyclonal gammopathy, so the γ-globulins
account for 62.4% of the serum proteins in contrast to the normal
level of 14.3%. (Courtesy Dr. S.H. An.)

The immune-complex–mediated lesions of Aleutian disease
include an arteritis, in which IgG, C3, and viral antigen are found

within vessel walls; and a glomerulonephritis, in which immune-
complexes are deposited in the kidneys. In addition, infected mink
are anemic because their red cells are coated with antiviral
antibodies. The red cells of infected animals adsorb virus-antibody

complexes from plasma. These coated red cells are then removed
from the circulation by macrophages. As might be predicted, the
use of immunosuppressive agents such as cyclophosphamide or

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