Page 610 - Clinical Small Animal Internal Medicine

578 Section 6 Gastrointestinal Disease

VetBooks.ir Table 53.3 Treatments for chronic idiopathic large bowel disease (CILBD) Comment
Dose
Class
Name
Fiber Psyllium Daily dose: Median dose was 1.3 g/kg/day in one
½ tablespoon for toy breeds study
1 tablespoon for small‐breed
dogs
2 tablespoons for medium‐
breed dogs
3 tablespoons for large‐breed
dogs
Canned pumpkin 1–4 tablespoons mixed with
food per day
Coarse wheat bran 1–4 tablespoons mixed with
food per day
Commercially available Feeding recommendation by Available from reputable pet food
diets with high fiber weight/the manufacturer manufacturers
contents
Motility‐modifying Loperamide 0.04–0.2 mg/kg PO q8–12h Not for prolonged use
agents
Diphenoxylate 0.05–0.1 mg/kg PO q6–8h Often in combined preparations with
atropine sulfate
Laxatives Lactulose 1 mL per 4.5 kg PO BID–TID Hyperosmotic
Bisacodyl 5–20 mg per dog PO SID Stimulant/prokinetic
Antispasmodics Chloriazepoxide (5 mg) 0.1–0.25 mg/kg clidiniium Librax®. Can be given prophylactically
(neurotropic) and clidinium bromide PO BID–TID for a few days or metaphylactically as well as
(2.5 mg) therapeutically
Propantheline 0.25 mg/kg PO TID (round Do not use for longer than 48–72 h
dose to nearest 3.75 mg)
Hyoscyamine 0.003–0.006 mg/ Not for prolonged use
kg PO BID–TID
Butylscopolamine/ 0.5–0.8 mg/kg PO SC IM or Inhibits M1 muscarinic acetylcholine
hyoscin IV SID–TID receptors in the GI and urinary tract,
does not cross blood–brain barrier.
Often in combination with metamizole
Dicyclomine 0.15 mg/kg BID–TID
Antispasmodics Mebeverine 2.5–5 mg/kg PO BID
(musculotropic)
Pinaverium 1 mg/kg PO BID
Trimebutine 0.33 mg/kg PO TID
Behavior‐modifiying Amitriptyline 1–2 mg/kg PO SID–BID The atypical tricyclic antidepressant
agents clomipramine exists as an authorized
preparation for use in dogs and is
claimed to have better anticompulsive
properties. Amitriptyline is bitter/
distasteful. Some caution and careful
monitoring are warranted in patients
with cardiac or renal disease
Selegiline 0.5–1 mg/kg PO SID Dopamine agonist. Dose can be
increased to 2 mg/kg SID if no
response after 2 months
Clomipramine 1–2 mg/kg PO BID Tricyclic antidepressant. Increase
gradually up to 3 mg/kg PO BID if
necessary after 14 days

Source: Modified from Lecoindre and Gaschen (2011). Reproduced with permission of Elsevier.
BID, twice a day (bis in die); IM, intramuscular; IV, intravenous; PO, by mouth (per os); SC, subcutaneous; SID, once a day (semel in die);
TID, three times a day (ter in die).