Page 202 - Veterinary Immunology, 10th Edition
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FIG. 7.6 The pathogenesis of the systemic inflammatory response
syndrome. In effect, the syndrome results from overexpression of
multiple cytokines. These cytokines trigger a series of events that
result in widespread cell death and multiple organ failure.
After massive tissue damage, large amounts of DAMPs including
HMGB1, mitochondrial components, and oxidants may escape into
the bloodstream and trigger a lethal form of shock, known as SIRS.
These DAMPs activate large numbers of sentinel cells and as a
result generate large quantities of inflammatory mediators such as
TNF-α, IFN-γ, CXCL8, and IL-6. They also generate large amounts
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